基于健康大数据带状疱疹与抑郁症的关系——现实世界的研究实例  

The study on the relationship between herpes zoster and depression based on Health Big Data—Real world research examples

作　　者：丁雄 蒋蔚[2] 蒋静[2] 胡跃华[3] 武英 李云 赵丹丹 殷大鹏[3] DING Xiong;JIANG Wei;JIANG Jing;HU Yue-hua;WU Ying;LI Yun;ZHAO Dan-dan;YIN Da-peng(School of Public Health,North China University of Science and Technology,Tangshan 063210,China;Yichang Center for Disease Control and Prevention,Yichang 443003,China;Office of Epidemiology,Chinese Center for Disease Control and Prevention,Beijing 102206,China)

机构地区：[1]华北理工大学公共卫生学院,唐山063210 [2]宜昌市疾病预防控制中心,宜昌443003 [3]中国疾病预防控制中心流行病学办公室,北京102206

出　　处：《中华疾病控制杂志》2021年第6期730-733,共4页Chinese Journal of Disease Control & Prevention

基　　金：2020年北京市自然科学基金(L202008);北航-首医大数据精准医疗高精尖创新中心计划(BHME-201801);中国疾病预防控制中心科研项目(59911917)

摘　　要：目的探讨宜昌市抑郁症与患带状疱疹风险的关系。方法根据中国宜昌市健康大数据,选取在2018年9月30日―2019年9月30日期间经临床医生诊断为带状疱疹的患者作为病例组,按年龄(组距为10岁)和性别进行1∶4匹配其他就诊者作为对照组。按就诊日期先确定抑郁症暴露,采用条件Logistic回归分析模型分析抑郁症与患带状疱疹风险的关系。结果共纳入5370例病例,匹配21480例对照,年龄为56(43,67)岁,病例组男性2533例,占47.17%,对照组中男性10132例,占47.17%。调整潜在混杂因素后,病例组抑郁症患者发生带状疱疹的风险是非抑郁症患者的1.697倍(OR=1.697,95%CI:1.089~2.643,P=0.019);在女性、就诊年龄<50岁和≥70岁人群中抑郁症与患带状疱疹有关联,OR值分别为1.983(95%CI:1.124~3.498,P=0.018)、2.213(95%CI:1.059~4.629,P=0.035)和2.738(95%CI:1.264~5.929,P=0.011)。结论抑郁症会增加罹患带状疱疹的风险,尤其是女性以及年龄在50岁以下和70岁及以上人群中。Objective The aim of our study was to explore the relationship between depression and the risk of herpes zoster in Yichang City.Methods With use of the Health Big Data of Yichang City,China,patients who were diagnosed with herpes zoster by clinicians between September 1,2018 to September 30,2019 were included.For each patient with herpes zoster,4 matched controls were identified,matched for age(class interval:10 years old)and sex.Controls took the index date of their matched case,and conditional Logistic regression analysis model was used to evaluate the relationship between depression and the risk of herpes zoster.Results In age was 56(43,67)years old,a total of 5370 cases were included and 21480 controls were matched.There were 2533 males(47.17%)in the case group and 10132 males(47.17%)in the control group.After adjusting for potential confounding factors,patients with depression had the 1.697 times risk of shingles as those without depression,the OR(odds ratio,OR)for case group was 1.697,(95%CI:1.089-2.643,P=0.019),compared with matched controls.This relationship also observed in female(OR=1.983,95%CI:1.124-3.498,P=0.018),age under 50 years old(OR=2.213,95%CI:1.059-4.629,P=0.035)and older than 70 years old(OR=2.738,95%CI:1.264-5.929,P=0.011).Conclusion The recent study suggested that depression may be a risk factor for herpes zoster,especially in females,individuals under 50 years old and older than 70 years old.

关 键 词：带状疱疹 抑郁症 大数据 

分 类 号：R752.1[医药卫生—皮肤病学与性病学] R749.4[医药卫生—临床医学]