^(18)F脱氧葡萄糖-正电子发射断层扫描/CT对预测皮肌炎肺间质病变进展的研究  

The prediction of disease progression by,^(18)Fluorodeoxyglucose-positron emission computed tomography/CT in patients with dermatomyositis and interstitial lung disease

作　　者：赵征[1] 李坤鹏[1] 王炎焱[1] 裴蕾[1] 关志伟[2] 金京玉[1] 朱剑[1] 张江林[1] 黄烽[1] Zhao Zheng;Li Kunpeng;Wang Yanyan;Pei Lei;Guan Zhiwei;Jin Jingyu;Zhu Jian;Zhang Jianglin;Huang Feng(Department of Rheumatology and Immunology,PLA General Hospital,Beijing 100853,China;Department of Nuclear Medicine,PLA General Hospital,Beijing 100853,China)

机构地区：[1]解放军总医院第一医学中心风湿免疫科,北京100853 [2]解放军总医院第一医学中心核医学科,北京100853

出　　处：《中华内科杂志》2021年第7期661-664,共4页Chinese Journal of Internal Medicine

摘　　要：探讨^(18)F脱氧葡萄糖(FDG)-正电子发射断层扫描(PET)/CT对皮肌炎(DM)肺间质病变进展的预测价值。选解放军总医院第一医学中心2012年1月至2017年9月收治并接受[^(18)F]FDG-PET/CT检查的DM患者,分析肺部标准化摄取值(SUV)对肺间质病变是否具有预测价值。共纳入DM患者67例,其中典型DM者45例,无肌病性皮肌炎(CADM)者22例。所有合并快速进展肺间质病变(RP-ILD)者红细胞沉降率(ESR)、肺部SUV高于合并缓慢进展型肺间质病变(C-ILD)者(P<0.05)。所有合并RP-ILD者,肺部SUV与年龄、病程、ESR呈正相关(r分别为0.441、0.361、0.293,均P=0.000)。受试者操作特征(ROC)曲线分析显示,对所有合并肺间质病变者,肺部SUV≥2.25时,诊断RP-ILD的敏感度为77.8%,特异度为72.8%。高龄、长病程、低肌酸激酶、ESR增快及肺部SUV高对预测DM相关肺间质病变具有显著相关性。To investigate the predictive value of[^(18)F]fluorodeoxyglucose-positron emission computed tomography(PET)/CT for disease progression in patients with dermatomyositis(DM)and interstitial lung diseases(ILD).Sixty-seven DM patients who underwent[^(18)F]FDG-PET/CT imaging were retrospectively analyzed from January 2012 to September 2017 at PLA General Hospital.Their clinical manifestations and imaging characteristics were recorded.Compared with those chronically progressed(C-ILD),patients with rapid progression(RP-ILD)had significantly higher erythrocyte sedimentation rate(ESR)and standardized uptake value(SUV)in lungs(P<0.05).In patients with RP-ILD,SUV in lungs was positively correlated with age,disease course,and ESR.Receiver operating characteristic curve analysis suggested that when lung SUV cut off value was 2.25,the sensitivity and specificity to predict disease progression was 77.8%and 72.8%,respectively.Old age,longer disease course,low creatine kinase level,higher ESR,and high SUV are prognostic factors for DM-associated ILD.

关 键 词：皮肌炎 肺疾病 间质性 ^(18)F脱氧葡萄糖(FDG)-正电子发射断层扫描/CT 

分 类 号：R593.26[医药卫生—内科学]