急性冠状动脉综合征患者冠脉内炎性因子水平与患者疾病状态关系  

Relationship between the level of inflammatory factors and disease state in patients with acute coronary syndrome

作　　者：宁萌[1] 彭文近[1] 刘艳红[1] 王辉[1] 马冠群 刘迎午[1] Ning Meng;Peng Wenjin;Liu Yanhong;Wang Hui;Ma Guanqun;Liu Yingwu(Department of Cardiology,Tianjin Third Central Hospital,Tianjin 300170,China)

机构地区：[1]天津市第三中心医院心脏科,300170

出　　处：《国际生物医学工程杂志》2021年第2期101-105,118,共6页International Journal of Biomedical Engineering

摘　　要：目的探讨急性冠脉综合征(ACS)患者冠脉血中炎性因子IL-1、IL-6、IL-10水平与梗死血管直径、术前血流、术后血流状态、冠脉病变支数以及其他危险因素之间的关系,以确定炎性因子和ACS之间的关系及其对临床状态的影响。方法于术前取54例ACS并行急诊介入治疗患者的外周血与冠脉血。用全自动生化分析仪检测血样中的IL-1、IL-6、IL-10水平。结果术后心脏不良事件与患者年龄、D-to-B时间、冠脉病变支数呈正相关(均P<0.05)。ACS患者冠脉血中IL-1、IL-6、IL-10水平均高于外周血(均P<0.05)。冠脉病变支数(≥3)、心梗发病时间(>4 h)、合并糖尿病、缺血后处理、术前血流级别2.5 mm、冠脉病变支数≥3、右冠脉严重病变、术前血流22帧、出现心血管事件的患者,其血液IL-10水平较高(均P<0.05)。结论ACS患者冠脉血中炎性因子IL-1、IL-6、IL-10水平高于外周血,提示急性冠脉起源于冠脉局部的炎症反应,外周血中炎性因子的升高属于“冲刷”效应,且炎性因子的水平与病变血管直径、术前血流、冠脉病变支数、心梗位置、合并糖尿病以及吸烟史有明显相关性。Objective To investigate the influence of infarct vessel diameter,blood flow before operation,blood flow status after operation,coronary artery disease,number of coronary artery lesions and other risk factors on the levels of inflammatory factors IL-1,IL-6,IL-10 in the coronary blood of patients with acute coronary syndrome(ACS),and to determine the relationship between inflammatory factors and ACS and its impact on clinical status.Methods The peripheral blood and coronary blood of 54 patients with ACS underwent emergency interventional treatment were collected before the operation.The level of IL-1,IL-6,and IL-10 in the blood sample was detected by an automatic biochemical analyzer.Results Postoperative adverse cardiac events were positively correlated with the patient's age,D-to-B time,and the number of coronary artery lesions(all P<0.05).The levels of IL-1,IL-6 and IL-10 in coronary blood of ACS patients were higher than those in peripheral blood(all P<0.05).The number of coronary artery disease branches(≥3),the onset time of myocardial infarction(>4 h),diabetes mellitus,ischemic post-treatment,preoperative blood flow level 2.5 mm,coronary artery disease number≥3,severe right coronary artery disease,preoperative blood flow 22 frames,and cardiovascular events,the IL-10 levels are higher(all P<0.05).Conclusions The levels of inflammatory factors IL-1,IL-6,and IL-10 in coronary blood of ACS patients are higher than those in peripheral blood,suggesting that acute coronary artery originates from local coronary inflammatory reaction,and the increase of inflammatory factors in peripheral blood belongs to"Erosion"effect.The level of inflammatory factors is significantly related to the diameter of the diseased blood vessel,preoperative blood flow,the number of coronary artery disease,the location of myocardial infarction,diabetes and smoking history.

关 键 词：急性冠脉综合征 炎性因子 冠脉病变 临床事件 

分 类 号：R541.4[医药卫生—心血管疾病]