肿瘤微环境响应药物递送系统的设计  

Rational Design of Tumor Microenvironment Responsive Drug Delivery Systems

作　　者：荆晓东 孙莹 于冰 申有青[3] 胡浩 丛海林 Xiaodong Jing;Ying Sun;Bing Yu;Youqing Shen;Hao Hu;Hailin Cong(Institute of Biomedical Materials and Engineering,College of Materials Science and Engineering,Qingdao University,Qingdao 266071,China;State Key Laboratory of Bio-Fibers and Eco-Textiles,College of Chemistry and Chemical Engineering,Qingdao University,Qingdao 266071,China;Center for Bionanoengineering and Key Laboratory of Biomass Chemical Engineering of Ministry of Education,College of Chemical and Biological Engineering,Zhejiang University,Hangzhou 310027,China)

机构地区：[1]青岛大学,材料科学与工程学院,生物医用材料与工程研究院,青岛266071 [2]青岛大学,化学化工学院,生物多糖纤维成形与生态纺织国家重点实验室,青岛266071 [3]浙江大学,化学工程与生物工程学院,生物质化工教育部重点实验室,杭州310027

出　　处：《化学进展》2021年第6期926-941,共16页Progress in Chemistry

基　　金：国家自然科学基金项目(No.51703105,21675091,21874078);山东省自然科学基金项目(No.ZR2017BEM012);山东省泰山青年学者计划(No.TSQN20161027);山东省重大科技创新项目(No.2018CXGC1407);山东省重点研究开发项目(No.2016GGX102028,2016GGX102039,2017GGX20111);中国博士后科学基金项目(No.2018M630752);青岛市创新创业领军人才项目(No.168325zhc);青岛市博士后科研基金项目;山东省一流学科项目资助。

摘　　要：化学药物治疗(化疗)是目前临床上治疗肿瘤最有效的方法之一,但传统的给药方式导致药物对肿瘤的靶向性差、药物利用率低。在杀伤肿瘤细胞的同时,化疗药物对人体正常细胞也有很大的损伤,因此在化疗过程中通常伴随着严重的副作用,例如恶心、呕吐以及脱发等。随着肿瘤学和纳米材料的迅速发展,多种纳米药物载体被应用于肿瘤的治疗。纳米药物载体具有提高药物利用率、降低药物的毒副作用等诸多优势,已成为药物递送领域的研究热点。其中,肿瘤微环境响应纳米药物载体在实现肿瘤部位药物的可控释放、载体保护壳的脱除以及肿瘤靶向等方面表现出优异的性能。本文讨论了基于肿瘤微环境的异常生化指标构建肿瘤微环境响应载体的常用策略,并总结了近年来肿瘤微环境响应纳米药物载体用于肿瘤治疗的研究进展,旨在为设计与制备高性能纳米药物载体提供参考。Chemotherapy is one of the most effective methods for cancer therapy in clinical practice,but the administration of chemotherapeutic drugs results in poor targeting of drugs to tumors and low utilization rates of drugs.While killing tumor cells,chemotherapeutic drugs also cause great damage to normal human cells,so chemotherapy is usually accompanied by serious side effects,such as nausea,vomiting,and hair loss.With the rapid development of oncology and nanomaterials,many nano-drug vectors have been used in the treatment of tumors.Nanometer drug vectors can improve the utilization rate of drugs and reduce side effects,which has become a research hotspot in the field of drug delivery.The tumor microenvironment responsive drug delivery systems have shown excellent performance in the controlled drug release,removal of the protective shell,and tumor targeting.In this paper,we discuss the common strategies for constructing tumor microenvironment responsive drug delivery systems based on abnormal biochemical indicators of tumor microenvironment or in tumor cells.The recent advances of tumor microenvironment responsive drug delivery systems are summarized.Finally,we outline the challenges and perspectives about the improvement of tumor microenvironment responsive drug delivery systems,aiming to provide a reference for the design and preparation of high-performance drug delivery systems.

关 键 词：肿瘤微环境 药物递送系统 刺激响应 载体设计 癌症治疗 

分 类 号：O631[理学—高分子化学] TB38[理学—化学]