液相悬浮阵列芯片在检验医学中的应用进展  

Progress in the application of liquid suspension array chip technology in clinical laboratory medicine

作　　者：李敏 豆小文 熊丹(综述) 张秀明(审校) LI Min;DOU Xiaowen;XIONG Dan;ZAHNG Xiuming(Medical College of Anhui University of Science and Technology,Huainan,Anhui 232000,China;Medical Laboratory,Shenzhen Luohu Hospital Group/Department of Clinical Laboratory,the Third Affiliated Hospital of Shenzhen University,Shenzhen,Guangdong 518001,China)

机构地区：[1]安徽理工大学医学院,安徽淮南232000 [2]深圳市罗湖医院集团医学检验实验室/深圳大学第三附属医院医学检验科,广东深圳518001

出　　处：《国际检验医学杂志》2021年第14期1777-1781,共5页International Journal of Laboratory Medicine

基　　金：国家自然科学基金面上项目(81703699);广东省深圳市科创委项目(201908123000612);广东省深圳市医学重点学科项目(SZXK054);广东省深圳市医疗卫生三名工程项目(SZSM201601062)。

摘　　要：液相悬浮阵列芯片技术作为一种新兴生物芯片技术,基于多指标联合和批量标本检测优势已广泛应用于临床诊断领域,尤其在蛋白质和核酸检测如细胞因子、激素、肿瘤标志物等方面发挥了重要临床价值。该文归纳了液相悬浮阵列芯片技术的检测原理和悬浮微球类别,总结其在主要临床检验领域包括病原体检测、自身免疫性疾病及肿瘤标志物筛查等中的应用进展,展望其在临床检验中面临的机遇和挑战。As a new biochip technology,liquid suspension array chip technology has been widely used in the field of clinical diagnosis based on the advantages of combined detection of multiple indicators and batch specimen test,especially in protein and nucleic acid detection,such as cytokines,hormones,tumor markers and other aspects.In this paper,we summarize the principles and categories of levitating microspheres of liquid phase suspension array technology,and focus on its application in major clinical laboratory areas,including pathogen detection,autoimmune diseases and tumor marker screening,and prospect the opportunities and challenges it faces in clinical laboratory.

关 键 词：液相悬浮阵列芯片 悬浮微球 高通量检测 临床检验医学 

分 类 号：R446.61[医药卫生—诊断学]