社区人群痛风患病率及相关影响因素分析  

The prevalence of gout and related factors in community population

作　　者：李安乐 赵根明[2] 王娜[2] 彭谦 季莹 邵月琴[1] 许文忠 石国政 Li Anle;Zhao Genming;Wang Na;Peng Qian;Ji Ying;Shao Yueqin;Xu Wenzhong;Shi Guozheng(Jiading District Center for Disease Control and Prevention,Shanghai 201800,China;Public Health School of Fudan University,Shanghai 200433,China;Jiading District Health Committee,Shanghai 201800,China)

机构地区：[1]上海嘉定区疾病预防控制中心,201800 [2]复旦大学公共卫生学院,上海200433 [3]上海嘉定区卫生健康委员会,201800

出　　处：《中华内分泌代谢杂志》2021年第6期542-547,共6页Chinese Journal of Endocrinology and Metabolism

基　　金：国家重点研发计划精准医学重点专项(2017YFC0907000);上海市高峰计划公共卫生与预防医学重点学科建设项目。

摘　　要：目的了解社区居民痛风患病情况及相关影响因素,为社区痛风的预防控制提供依据。方法采用多阶段随机抽样方法,对抽中的3个街道(镇)的20~75岁常住居民进行调查,用SPSS统计软件对调查数据进行统计分析,用logistic回归分析法进行单因素分析。结果上海嘉定区居民高尿酸血症与痛风的平均患病率分别为9.82%与5.75%,其中男性为18.88%与7.94%、女性为3.79%与4.29%。社区痛风患病人群中,家族史阳性率为17.13%,家族史与痛风的关系显著(OR=3.140,95%CI 2.365~4.169,P<0.01)。年龄(OR=1.034,95%CI 1.021~1.047)、体重指数(OR=1.102,95%CI 1.074~1.131)、腰臀比(OR=4.876,95%CI 1.153~20.622)、睡眠质量(OR=1.310,95%CI 1.159~1.480)以及食用猪肉外的其他畜肉(OR=1.117,95%CI 1.007~1.240)、淡水鱼类(OR=1.138,95%CI 1.005~1.288)、加工肉制品(OR=1.145,95%CI 1.033~1.270)与痛风显著相关(P<0.05或P<0.01)。性别、饮酒、食用海水鱼类、豆浆/豆奶也与痛风患病相关(P<0.05或P<0.01),表现为保护作用(OR<1.000)。结论少吃畜肉与肉制品等高嘌呤食物,以及控制体重,可能有助于减少尿酸的产生,达到预防痛风的目的。Objective To explore the prevalence of gout and related factors in community population,thereby provide evidence for comprehensive prevention and control of gout in community.Methods A stratified multi-stage cluster sampling was used to survey the permanent residents of 20 to 75 years old in the 3 selected streets(towns),univariate analysis was performed using logistic regression by SPSS statistical software.Results The prevalences of hyperuricemia and gout were 9.82%and 5.75%respectively(male 18.88%and 7.94%,female 3.79%and 4.29%)in Jiading Shanghai.The positive rate of family history was 17.13%,and the relationship between family history and gout was significant(OR=3.140,95%CI 2.365-4.169,P<0.01).Age(OR=1.034,95%CI 1.021-1.047),body mass index(OR=1.102,95%CI 1.074-1.131),waist-hip ratio(OR=4.876,95%CI 1.153-20.622),sleep quality(OR=1.310,95%CI 1.159-1.480),other animal meat(OR=1.117,95%CI 1.007-1.240),fresh water fish(OR=1.138,95%CI 1.005-1.288),and processed meat(OR=1.145,95%CI 1.033-1.270)were closely related to gout(P<0.05 or P<0.01).Sex,alcohol drinking,marine fish,and soybean milk/soymilk were related to gout(P<0.05 or P<0.01),but showed a protective effect(OR<1.000).Conclusion Reducing uric acid production through less consumption of purine-rich food such as animal meat as well as processed meat and weight control would be helpful in preventing gout.

关 键 词：痛风 社区 患病率 影响因素 家族史 饮食营养 预防 

分 类 号：R589.7[医药卫生—内分泌]