猪链球菌生物被膜形成的耐药机制  

Biofilm-associated drug resistance in Streptococcus suis

作　　者：靳曼玉 李金朋 易力[2] 汪洋[1] Manyu Jin;Jinpeng Li;Li Yi;Yang Wang(College of Animal Science and Technology,Henan University of Science and Technology,Luoyang 471003,Henan Province,China;College of Life Sciences,Luoyang Normal University,Luoyang 471022,Henan Province,China)

机构地区：[1]河南科技大学动物科技学院,河南洛阳471003 [2]洛阳师范学院生命科学学院,河南洛阳471022

出　　处：《微生物学报》2021年第7期1829-1838,共10页Acta Microbiologica Sinica

基　　金：国家自然科学基金(31902309,31772761)。

摘　　要：猪链球菌病(Streptococcus suis)是一种严重影响各国养猪业发展和人类健康的人兽共患传染病,可以引起败血症、关节炎、脑膜炎等多种疾病,造成巨大的经济损失。猪链球菌生物被膜的形成是导致其致病性和耐药性增加的主要原因。为了预防和治疗猪链球菌病以及解析其耐药的可能机制,深入了解和掌握猪链球菌生物被膜的形成和耐药机制具有重要意义。本文综述了猪链球菌生物被膜形成和耐药机制的最新科学知识,着重从生化因素、生理因素、分子机制和环境改变等方面总结讨论猪链球菌生物被膜的耐药机制,进一步为该病的防治提供科学的理论依据。Streptococcus suis is a human-zoonotic infectious disease that seriously affects the pig industry and human health in various countries.It can cause septicemia,arthritis,meningitis and other diseases,thus causing huge economic losses.The biofilm formation is the main cause of increasing pathogenicity and drug resistance of S.suis.It is of great significance to understand and master the biofilm formation and drug resistance mechanism of S.suis,and to find the effective method of removing biofilm for the prevention and treatment of S.suis.This review updates the latest scientific knowledge about the formation and drug resistance mechanism of S.suis biofilm,focusing on biochemical factors,physiological factors,molecular mechanism and environmental changes,etc.,to summarize and discuss the drug resistance mechanism of S.suis biofilm,to provide a scientific theoretical basis for the prevention and treatment of the disease.

关 键 词：猪链球菌 生物被膜 抗生素 耐药机制 

分 类 号：S852.61[农业科学—基础兽医学]