上尿路结石急诊术围术期NLR、CRP、KIM-1变化及对SIRS诊断价值  

Changes of NLR,CRP,KIM-1 in the perioperative period of emergency surgery for upper urinary calculi and their diagnostic value for SIRS

作　　者：杨永刚 李外兴 李喆 伍小军 YANG Yonggang;LI Waixing;LI Zhe;WU Xiaojun(Department of Emergency Medicine,Longhua District People's Hospital,Shenzhen,Gangdong,China,518109)

机构地区：[1]深圳市龙华区人民医院急诊医学科,广东深圳518109

出　　处：《分子诊断与治疗杂志》2021年第6期961-964,共4页Journal of Molecular Diagnostics and Therapy

基　　金：深圳市宝安区社会公益基金项目(2016CX050)。

摘　　要：目的探讨上尿路结石急诊术围术期中性粒细胞/淋巴细胞比值(NLR)、C反应蛋白(CRP)、尿肾损伤分子-1(KIM-1)变化及对全身炎症反应综合征(SIRS)诊断价值。方法选取本院98例上尿路结石急诊术患者,根据术后是否发生SIRS分为SIRS组(n=16)、非SIRS组(n=82)。比较两组一般资料、围术期NLR、CRP、KIM-1水平,分析各指标与SIRS评分相关性及诊断SIRS的价值。结果 SIRS组确诊后NLR、CRP、KIM-1高于非SIRS组(P<0.05);确诊后NLR、CRP、KIM-1与SIRS评分间存在正相关关系(P<0.05);NLR、CRP、KIM-1诊断SIRS的曲线下面积(AUC)均在0.7以上,各指标联合诊断的AUC最大,为0.963。结论上尿路结石急诊术后NLR、CRP、KIM-1水平明显升高对临床诊断SIRS具有良好应用价值。Objective To investigate the perioperative changes of neutrophils lymphocytes ratio(NLR),C-reactive protein(CRP),kidney injury molecule-1(KIM-1)during emergency surgery for upper urinary tract stones and their diagnostic value for systemic inflammatory response syndrome(SIRS). Methods A total of 98 patients undergoing emergency surgery for upper urinary calculi in our hospital were selected and divided into the SIRS group(n=16)and the non-SIRS group(n=82)according to whether SIRS occurred after surgery. The general data,perioperative NLR,CRP,and KIM-1 levels in the two groups were compared,and the correlation between each indicator and the SIRS score and its diagnostic value for SIRS were analyzed.Results After diagnosis,NLR,CRP,and KIM-1 in the SIRS group were higher than those in the non-SIRS group(P<0.05). After diagnosis,there was a positive correlation between NLR,CRP,KIM-1 and SIRS score(P<0.05). The area under the curve(AUC)of NLR,CRP,and KIM-1 in the diagnosis of SIRS were all above0.7,and the AUC of the combined diagnosis of each indicator was the largest,which was 0.963. Conclusion The level of NLR,CRP,and KIM-1 increased significantly after emergency surgery for upper urinary calculi,which has good application value for the clinical diagnosis of SIRS.

关 键 词：上尿路结石 全身炎症反应综合征 中性粒细胞/淋巴细胞比值 C反应蛋白 尿肾损伤分子-1 

分 类 号：R699[医药卫生—泌尿科学]