长江中下游单中心气候因素对腹膜透析相关腹膜炎的影响分析  

Analysis on influence of monocentric climate factor in middle and lower reaches of Yangtze River on peritoneal dialysis-related peritonitis

作　　者：施钊钰 王聪 李海燕[1] 商芳芳 吴建华[1] 黄希[3] 袁莉[1] SHI Zhaoyu;WANG Cong;LI Haiyan;SHANG Fangfang;WU Jianhua;HUANG Xi;YUAN Li(Department of Nephrology,Affiliated Hospital of Nantong University,Nantong,Jiangsu 226200,China;Department of Nephrology,Yuhang District First People′s Hospital, Hangzhou,Zhejiang 310000,China;Nantong University,Nantong,Jiangsu 226200,China)

机构地区：[1]南通大学附属医院肾内科,江苏南通226200 [2]浙江省杭州市余杭区第一人民医院肾内科,310000 [3]南通大学,江苏南通226200

出　　处：《重庆医学》2021年第14期2389-2392,共4页Chongqing medicine

基　　金：国家自然科学基金青年基金项目(81200490);江苏省研究生科研与创新计划项目(SJCX19_0874);江苏省中医药科技发展计划项目(YB201985);南通市科技局项目(MS12017017-7)。

摘　　要：目的探讨气候因素对长江中下游腹膜透析相关腹膜炎(PDAP)的影响,为腹膜炎的发生、预防和治疗提供依据。方法回顾性分析南通大学附属医院腹膜透析中心2014年1月至2017年12月接受腹膜透析(PD)及发生PDAP患者的临床资料。分析气候因素(包括季节、梅雨季节、平均温度、平均湿度、平均降雨量)对PDAP影响。结果春夏秋冬的发病率分别为每100例患者月发生19.2、35.8、21.6、18.2例次,夏季发病率最高,与其他3个季节差异有统计学意义(P<0.01)。PDAP与平均湿度,平均温度及平均降雨量无明显相关性(r=-0.53、-0.56、-0.43,P>0.05)。梅雨季节发病率为每100例患者月发生36.6次,高于非梅雨季节的21.6次(P<0.05)。梅雨及非梅雨季间致病菌谱差异无统计学意义,革兰阳性球菌比率均大于50%,其中以表皮葡萄球菌为主。结论PDAP与季节有相关性,夏季发病率最高,梅雨季节PDAP发生率高于非梅雨季节。Objective To investigate the influence of climate factors in the middle-lower reaches of Yangtze River on peritoneal dialysis(PD)-associated peritonitis(PDAP)so as to provide a basis for the occurrence,prevention and treatment of peritonitis.Methods The clinical data of the patients receiving PD and the patients with PDAP occurrence in the peritoneal dialysis center of the Affiliated Hospital of Nantong University from January 2014 to December 2017 were retrospectively analyzed.The influence of climate factors(including seasons,plum rain season,average temperature,average humidity,average rainfall)on PDAP was analyzed.Results The incidence rates in spring,summer,autumn and winter were 19.2,35.8,21.6,18.2 cases-times for monthly occurrence per 100 cases.The incidence rate in summer was the highest,showing the statistical difference compared with other seasons(P<0.01).PDAP had no significant correlation with average humidity,average temperature and average rainfall(r=-0.53,r=-0.56,r=-0.43,P>0.05).The incidence rate in the plum rain season was 36.6 times for monthly occurrence per 100 patients,which was higher than 21.6 times in the non-plum seasons.The difference in pathogenic bacterial spectrum between the plum rain season and non-plum rain season had no statistical significance.The ratio of Gram-positive cocci all was>50%,which was mainly Staphylococcus epidermidis.Conclusion PDAP has the correlation with the seasons,the summer had the highest incidence rate.The PDAP incidence rate of plum rain season is higher than that of non-plum rain season.

关 键 词：腹膜透析 腹膜炎 气候 致病菌 

分 类 号：R656.4[医药卫生—外科学]