脐带血血型血清学检测在新生儿溶血病中的应用  

Application of blood group serological testing of umbilical cord blood in neonatal hemolytic disease

作　　者：刘娟[1] 陈勇 唐海东 谭美芳 潘枫[1] 熊德琼 张泽君[1] 冯晨程 李维 LIU Juan;CHEN Yong;TANG Haidong;TAN Meifang;PAN Feng;XIONG Deqiong;ZHANG Zejun;FENG Chencheng;LI Wei(Department of Blood Transfusion,Dazhou Municipal Hospital of Integrated Traditional Chinese and Western Medicine,Dazhou,Sichuang 635001,China;Department of Clinical Laboratory,Naxi District Peoples Hospital,Luzhou,Sichuan 646000,China;Department of Component,Dazhou Municipal Central Blood Station,Dazhou,Sichuan 635001,China)

机构地区：[1]四川省达州市中西医结合医院输血科,635001 [2]四川省泸州市纳溪区人民医院检验科,646000 [3]四川省达州市中心血站成分科,635001

出　　处：《重庆医学》2021年第14期2492-2495,共4页Chongqing medicine

基　　金：四川省达州市卫生健康委员会科研项目(201708)。

摘　　要：目的探讨脐带血血型血清学检测在新生儿溶血病(HDN)早期诊断中的应用价值。方法对2017年1月至2019年10月达州市中西医结合医院正常分娩的产妇脐带血做血红蛋白(Hb)、总胆红素(TSB)、ABO血型、RhD血型检测,对于母婴ABO血型不合(O-A、O-B、O-AB)、母婴其他血型(O-O、非O-A、B、AB、Rh系统抗-D除外)中母亲不规则抗体筛查阳性的新生儿脐带血做新生儿溶血3项试验。结果1969例脐带血标本母婴血型O-A型476例,确诊HDN 127例(26.68%),O-B型339例,确诊HDN 76例(22.42%),O-AB型42例,确诊HDN 3例(7.14%),1112例母婴其他血型中母亲不规则抗体筛查阳性28例,确诊HDN 19例(1.71%)。结论脐带血血型血清学检测在新生儿溶血病中的应用效果显著。Objective To explore the application value of blood group serological detection of umbilical cord blood in the early diagnosis of hemolytic disease of newborn(HDN)in basic medical institutions.Methods Hemoglobin(Hb),total bilirubin(TSB),ABO blood group,and RhD blood group of umbilical cord blood in the parturients with normal labor in the Dazhou Municipal Hospital of Integrated Traditional Chinese and Western Medicine from January 2017 to October 2019 were detected.The neonatal umbilical cord blood of maternal irregular antibody screening positive for the maternal and infant ABO blood group incompatibility(O-A,O-B,O-AB)and maternal and infant other blood groups(O-O,non-O-A,B,AB,except for anti-D in Rh system)conducted the neonatal hemolytic 3-item test.Results Among 1969 umbilical cord blood samples,in 476 cases of mother and infant blood group O-A group,127 cases(26.68%)were diagnosed as HDN;in 339 cases of O-B group,76 cases(22.42%)were diagnosed as HDN;in 42 cases of O-AB group,3 cases(7.14%)were diagnosed as HDN,in 1112 cases of other maternal and infant blood groups,28 cases were detected positive in maternal irregular antibody screening,19 cases(1.71%)were definitely diagnosed as HDN.Conclusion The application effect of the umbilical cord blood group serological testing is effective in neonatal hemolytic disease.

关 键 词：新生儿溶血病 血型 基层医疗机构 脐带血 诊断 

分 类 号：R556.63[医药卫生—血液循环系统疾病]