Mosaic isodicentric Y chromosome harboring intact AZF region in a cryptozoospermic male with normal hormone levels  

作　　者：Sheng-Yu Xie Da-Chang Tao Yuan Yang 

机构地区：[1]Department of Medical Genetics,State Key Laboratory of Biotherapy,West China Hospital,West China Medical School,Sichuan University,Chengdu 610041,China

出　　处：《Asian Journal of Andrology》2021年第4期437-438,共2页亚洲男性学杂志（英文版）

基　　金：The National Natural Science Foundation of China(No.81871203)supported the study.

摘　　要：Dear Editor,Structural aberrations of the Y chromosome,including deletions,ring chromosomes,Y-autosomal or Y-X translocations,isochromosomes,and dicentrics,occur in approximately 0.2%of live births;1 among these,partial deletion in the azoospermia factor(AZF)region of the Y chromosome is a well-characterized cause of nonobstructive severe oligozoospermia and azoospermia.2 Meanwhile,a dicentric Y chromosome,abbreviated as dic(Y),was observed to be exclusively present in males with azoospermia,suggesting more severe negative consequences of the AZF deletion for spermatogenesis.

关 键 词：MOSAIC HARBOR AZF 

分 类 号：R321.1[医药卫生—人体解剖和组织胚胎学]