抗体技术的研发现状与展望  

Development and prospect of antibody technology

作　　者：武瑞君 桑晓冬 李治非 敖翼[1] 范玲 WU Rui-jun;SANG Xiao-dong;LI Zhi-fei;AO Yi;FAN Ling(China National Center for Biotechnology Development,Beijing 100039,China)

机构地区：[1]中国生物技术发展中心,北京100039

出　　处：《中国药理学与毒理学杂志》2021年第5期374-381,共8页Chinese Journal of Pharmacology and Toxicology

摘　　要：伴随着抗体的发现和对抗体认识的不断加深,抗体技术的研究正在不断拓展,同时抗体技术的创新加速了新的抗体药物的研发和生产水平的提升。根据发展历程,抗体技术分为多克隆抗体技术、杂交瘤单克隆抗体技术和基因工程抗体技术3个阶段。目前,最新抗体技术主要有杂交瘤单克隆抗体技术、抗体文库展示技术、转基因动物技术和单细胞测序技术等,各有不同的优势和劣势。加强基础研究,创新抗体技术等关键核心技术,提升创新药物研发技术平台能力建设,不断将变革性新技术应用于抗体等药物的研发,对推动我国抗体药物自主研发乃至新药创制具有重要意义。With the discovery and better understanding of antibodies,the research on antibody technology keeps expanding.Meanwhile,the innovation of antibody technology has accelerated the development of new antibody drugs and improved productivity.According to the process of development,antibody technology is divided into three stages:polyclonal antibody technology,hybridoma monoclonal antibody technology and genetic engineering antibody technology.The latest antibody technologies include hybridoma monoclonal antibody technology,antibody library display technology,transgenic animal technology and single-cell sequencing technology,each with different advantages and disadvantages.It is of great importance to upgrade basic research,innovate key technologies such as antibody technology,improve platform capacity construction,and continuously apply transformative new technologies to the research of antibodies and other drugs to promote the development of drugs in China.

关 键 词：抗体技术 杂交瘤单克隆抗体技术 抗体文库展示技术 转基因动物技术 单细胞测序技术 

分 类 号：R392-33[医药卫生—免疫学]