药学服务对慢性阻塞性肺疾病患者噻托溴铵粉雾剂使用正确率、依从性和疗效的影响  

Effects of Pharmaceutical Service on the Correct Use,Compliance and Efficacy of Tiotropium Bromide Powder Spray in Patients with Chronic Obstructive Pulmonary Disease

作　　者：周丽华 许红蕾 邱景伟 ZHOU Lihua;XU Honglei;QIU Jingwei(Clinical Trial Institution,the 983th Hospital of Joint Logistics Support Forces of PLA,Tianjin 300142,China;Dept.of Respiratory Medicine,the 983th Hospital of Joint Logistics Support Forces of PLA,Tianjin 300142,China)

机构地区：[1]中国人民解放军联勤保障部队第九八三医院临床试验机构,天津300142 [2]中国人民解放军联勤保障部队第九八三医院呼吸内科,天津300142

出　　处：《中国医院用药评价与分析》2021年第6期741-744,共4页Evaluation and Analysis of Drug-use in Hospitals of China

基　　金：天津市卫生行业重点攻关项目(No.18KG113)。

摘　　要：目的:探讨药学服务对慢性阻塞性肺疾病(chronic obstructive pulmonary disease,COPD)患者噻托溴铵粉雾剂使用正确率、依从性和疗效的影响。方法:选择2018年2月至2019年8月于中国人民解放军联勤保障部队第九八三医院就诊的105例COPD患者作为研究对象,依据入院就诊先后顺序,按随机数字表法将患者分为两组,对照组52例患者未予以任何干预,研究组53例患者予以药学服务干预。比较两组患者噻托溴铵粉雾剂使用正确率、依从性,比较随访12个月两组患者的疗效、肺功能和改良英国医学研究学会呼吸困难指数(modified British medical research council,m MRC)分级。结果:(1)随访6、12个月时,研究组患者噻托溴铵粉雾剂使用正确率、Morisky服药依从性量表(Morisky medication adherence scale-8,MMAS-8)评分、第1秒用力呼气容积(FEV1)以及FEV1与用力肺活量(FVC)的比值(FEV1/FVC)均明显高于入组1个月时,m MRC分级均明显低于入组1个月时,上述差异均有统计学意义(P <0.05)。(2)随访12个月时,研究组患者噻托溴铵粉雾剂使用正确率、MMAS-8评分、FEV1以及FEV1/FVC均明显高于随访6个月时,m MRC分级明显低于随访6个月时,上述差异均有统计学意义(P <0.05)。(3)随访6、12个月时,研究组患者噻托溴铵粉雾剂使用正确率、MMAS-8评分、FEV1以及FEV1/FVC均明显高于对照组,m MRC分级均明显低于对照组,上述差异均有统计学意义(P <0.05)。(4)随访12个月时,研究组患者的总有效率明显高于对照组,差异有统计学意义(P <0.05)。结论:药学服务能显著提高COPD患者噻托溴铵粉雾剂使用正确率、依从性和疗效,改善患者的肺功能,减轻呼吸困难程度。OBJECTIVE: To probe into the effects of pharmaceutical service on the correct use,compliance and efficacy of tiotropium bromide powder spray in patients with chronic obstructive pulmonary disease( COPD).METHODS: Totally 105 COPD patients admitted into the 983 th Hospital of Joint Logistics Support Forces of PLA from Feb. 2018 to Aug. 2019 were selected as subjects,according to the order of admission and treatment,the patients were divided into two groups via random number table,52 patients in control group did not receive any intervention,while the 53 patients in research group received pharmaceutical service intervention. The correct rate of use and compliance of tiotropium bromide powder spray were compared between two groups,the efficacy,pulmonary function and modified British medical research council( m MRC) rating were compared between two groups in 12-month follow-up visit.RESULTS:( 1) At 6-month and 12-month follow-up visit,the correct rate of use,score of Morisky medication adherence scale-8( MMAS-8),forced expiratory volume in 1 s( FEV1),the ratio of FEV1 and forced vital capacity( FVC) of research group were significantly higher those at 1 month of enrollment,and the m MRC ratings were significantly lower than that at 1 month of enrollment,with statistically significant differences( P < 0. 05).( 2) At12-month follow-up visit,the correct rate of tiotropium bromide powder spray use,MMAS-8 score,FEV1 and FEV1/FVC of the research group were significantly higher than those at 6-month follow-up visit,and the m MRC rating was significantly lower than that at 6-month follow-up visit,with statistically significant differences( P < 0. 05).( 3) At6-month and 12-month follow-up visit,the correct rate of tiotropium bromide powder spray use,MMAS-8 score,FEV1 and FEV1/FVC of the research group were significantly higher than those of the control group,and the m MRC rating was significantly lower than that of the control group,with statistically significant differences( P < 0. 05).( 4) At12-month follow-up visit,the ove

关 键 词：药学服务 慢性阻塞性肺疾病 噻托溴铵粉雾剂 使用正确率 依从性 疗效 

分 类 号：R971.92[医药卫生—药品]