Mechanically-induced vasospasm-revaluation of spasmolytic efficacy of 10 pharmaceutical agents using LSCI  

作　　者：Zhuang Yuehong Ma Qiming 

机构地区：[1]Fujian Medical University,Fuzhou 350108,China

出　　处：《解剖学杂志》2021年第S01期33-33,共1页Chinese Journal of Anatomy

摘　　要：Vasospasm is a thorny problem often encountered in microvascular surgery.This investigation is dedicated to establishing a model of vasospasm and to evaluating the antispasmodic efficacy of 10 pharmacologic agents under direct monitoring of laser speckle contrast imaging(LSCI).80 SD rats were used.A pair of microsurgical forceps were used to trigger vasospasm of the femoral vessels by blunt dissection.Five minutes later,10 pharmacological agents were dripped to the femoral vessels,after which LSCI was used to collect perfusion images,acquiring the perfusion intensity and the inner caliber of the femoral vessels at multiple time points.

关 键 词：SPASM VASOSPASM PERFUSION 

分 类 号：R68[医药卫生—骨科学]