基于“阴阳消长转化”理论分期针灸法治疗早发性卵巢功能不全临床观察  

Acupuncture-moxibustion treatment by stages based on the theory of "transformation of yin and yang" for premature ovarian insufficiency

作　　者：王琳琳[1] 项云改[1] 谭丽[1] 朱敬云[1] 任志欣[1] 马晓英[1] 吴艳荣[1] WANG Lin-lin;XIANG Yun-gai;TAN Li;ZHU Jing-yun;REN Zhi-xin;MA Xiao-ying;WU Yan-rong(Department of Acupuncture-Moxibustion and Physiotherapy,Second Affiliated Hospital of Zhengzhou University,Zhengzhou 450014,Henan Province,China)

机构地区：[1]郑州大学第二附属医院针灸理疗科,河南郑州450014

出　　处：《中国针灸》2021年第7期742-746,共5页Chinese Acupuncture & Moxibustion

基　　金：河南省卫生厅科技攻关项目:201702085。

摘　　要：目的:比较分期针灸法与芬吗通治疗早发性卵巢功能不全(POI)的疗效。方法:将66例POI患者随机分为观察组(33例,脱落3例)和对照组(33例,脱落2例)。观察组基于"阴阳消长转化"理论,于经后期、排卵期、经前期、行经期采用分期针灸法治疗,隔日1次,每周治疗3次。对照组口服芬吗通(雌二醇片/雌二醇地屈孕酮片,每日1片)治疗。两组均连续治疗3个月经周期。观察两组患者治疗前后卵巢功能[血清卵泡刺激素(FSH)、促黄体生成素(LH)、雌二醇(E_(2))、抗苗勒管激素(AMH)水平及窦卵泡计数(AFC)]及围绝经期症状[改良Kupperman指数(KI)量表评分],并比较两组患者治疗后的月经改善情况。结果:与治疗前比较,两组患者治疗后血清FSH、LH水平下降(P<0.01),E_(2)水平升高(P<0.01);观察组患者治疗后血清AMH水平及AFC升高(P<0.01)。观察组患者治疗后血清AMH水平及AFC均高于对照组(P<0.05)。治疗后两组闭经患者月经回潮率及患者月经规律率比较差异均无统计学意义(P>0.05)。治疗后两组患者改良KI量表评分均较治疗前降低(P<0.01),且观察组低于对照组(P<0.05)。结论:基于"阴阳消长转化"理论的分期针灸法在改善POI患者血清性激素水平及月经症状方面与芬吗通疗效相似,在提高血清AMH水平、AFC及改善围绝经期症状方面较芬吗通具有优势。Objective To compare the efficacy between acupuncture-moxibustion treatment by stages and femoston for premature ovarian insufficiency(POI). Methods A total of 66 patients with POI were randomly divided into an observation group(33 cases, 3 cases dropped off) and a control group(33 cases, 2 cases dropped off). The patients in the observation group, based on the theory of "transformation of yin and yang", were treated with acupuncture-moxibustion by stages in the postmenstrual period, ovulatory period, premenstrual period and menstrual period, once every other day, 3 times a week. The patients in the control group were treated with oral administration of femoston(estradiol tablets/estradiol and dydrogesterone tablets, 1 tablet per day). Both groups were treated for 3 menstrual cycles. The ovarian function(serum follicle-stimulating hormone [FSH], luteinizing hormone [LH], estradiol [E_(2)], anti-mullerian hormone [AMH] and antral follicle count [AFC]) and perimenopausal symptoms [modified Kupperman index(KI) scale score] were observed before and after treatment, and the menstrual improvement of the two groups was compared. Results Compared before treatment, the serum levels of FSH and LH were decreased(P<0.01), the levels of E_(2) were increased(P<0.01) in the two groups after treatment;the serum level of AMH and AFC in the observation group were increased after treatment(P<0.01). After treatment, the serum level of AMH and AFC in the observation group were higher than those in the control group(P<0.05). After treatment, there was no significant difference in the menstrual return rate and menstrual regularity rate between the amenorrhea patients of the two groups(P>0.05). After treatment, the modified KI scale scores in the two groups were reduced(P<0.01), and the modified KI scale score in the observation group was lower than that in the control group(P<0.05). Conclusion Acupuncturemoxibustion treatment by stages based on the theory of "transformation of yin and yang" has similar efficacy with femoston in improvi

关 键 词：早发性卵巢功能不全 分期针灸法 阴阳消长转化 血清性激素 围绝经期症状 

分 类 号：R246.3[医药卫生—针灸推拿学]