帕托珠利混悬液对靶动物仔猪的安全性评价  

Target animal safety of ponazuril suspension in suckling piglets

作　　者：王震 许琴瑟[3] 张伟[3] 高嫣珺 聂雅 霍皓远 肖文华[3] 卜仕金[1,2] WANG Zhen;XU Qinse;ZHANG Wei;GAO Yanjun;NIE Ya;HUO Haoyuan;XIAO Wenhua;PU Shijin(College of Veterinary Medicine,Yangzhou University,Yangzhou 225009,China;Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses,Yangzhou 225009,China;Jiangsu Agri-animal Husbandry Vocational College,Taizhou 225300,China)

机构地区：[1]扬州大学兽医学院,江苏扬州225009 [2]江苏省动物重要疫病与人兽共患病防控协同创新中心,江苏扬州225009 [3]江苏农牧科技职业学院,江苏泰州225300

出　　处：《畜牧与兽医》2021年第7期40-46,共7页Animal Husbandry & Veterinary Medicine

基　　金：江苏高校优势学科建设工程资助项目(PAPD)。

摘　　要：为研究帕托珠利混悬液对靶动物仔猪的安全性,本试验选取32只3~5日龄哺乳仔猪,分为4个剂量组,每组8头,公母各半。其中各剂量组按体重给药剂量分别为1倍(15 mg/kg)、3倍(45 mg/kg)和5倍(75 mg/kg)最大推荐剂量,经口灌服5%帕托珠利混悬液,连用3次,每次间隔3 d;另一组为空白对照组,给予相当于5倍最大推荐剂量体积的生理盐水,试验周期为17 d。试验期间除进行一般临床健康状况观察外,还进行体重增重、体温、血常规和血液生化指标检测,以及大体剖检和组织病理学检查。结果显示,试验期间试验组和对照组临床表现正常,帕托珠利混悬液各剂量组对仔猪的精神状态、生长性能、血常规、血液生化指标均无明显影响,均处正常范围内。对5倍推荐剂量组及对照组的仔猪进行剖检,主要脏器和显微结构未见明显异变,未出现中毒及死亡。研究表明,推荐剂量下帕托珠利混悬液口服给药对靶动物仔猪有较大安全性。In order to study the safety of ponazuril suspension in target piglets,32 sucking piglets aged 3-5 days were divided into 4 groups with 8 piglets in each(half males and half females)in this experiment.Swine safety studies were performed with multiple dose levels of the drug given in the intended market formulation.The dose levels of 5%ponazuril suspension included 0(for the control group),1×(15 mg/kg for test groupⅠ),3×(45 mg/kg for test groupⅡ),and 5×(75 mg/kg for test groupⅢ).The tested drug was orally administrated for 3 consecutive times,at an interval of 3 days.The control group was given 5×,the maximum recommended dose of normal saline.The experiment lasted for 17 days;during which periodic weighing,suckling,clinical observations,and physical examinations were performed,and hematology and blood and serum chemistries,as well as gross autopsy and histopathological examination,were carried out in predetermined periods of time.The results showed that,by the end of the trial,there had been no death of the piglets,all of which were clinically normal.No pathologic lesions were found at autopsy for all the test animals.The histopathological examinations in the 5×recommended dose group and the control group did not identify any abnormal tissue lesions.In conclusion,5%ponazuril suspension was of greater safety for piglets according to the recommended dosing schedule.

关 键 词：帕托珠利混悬液 靶动物安全性 仔猪 

分 类 号：S859.8[农业科学—临床兽医学]