氯己定与聚维酮碘预防手术部位感染效果比较的Meta分析  

Comparative analysis of effect of chlorhexidine and povidone⁃iodine on preventing surgical site infection:a systematic evaluation

作　　者：刘剑[1] 王云[1] 付裕 LIU Jian;WANG Yun;FU Yu(The Fifth Affiliated Hospital of Guangzhou Medical University,Guangdong 510700 China)

机构地区：[1]广州医科大学附属第五医院,广东510700

出　　处：《护理研究》2021年第14期2497-2503,共7页Chinese Nursing Research

摘　　要：目的:系统评价氯己定与聚维酮碘预防手术部位感染的效果。方法:计算机检索中国知网、万方数据库、维普网、PubMed、EMbase、The Cochrane Library等数据库中关于氯己定与聚维酮碘消毒预防手术部位感染的随机对照研究,检索时限为建库至2020年7月5日。2名研究员独立完成文献筛选、数据提取和质量评价后,采用RevMan 5.3软件进行Meta分析。结果:共纳入19篇文献。Meta分析结果显示,接受氯己定消毒的病人手术部位总感染率[RR=0.67,95%CI(0.58,0.77),P<0.000 01]、表浅手术切口感染率[RR=0.54,95%CI(0.42,0.70),P<0.000 01]及深部手术切口感染率[RR=0.54,95%CI(0.33,0.88),P=0.01]低于接受聚维酮碘消毒的病人。结论:现有证据表明,与聚维酮碘相比,氯己定预防手术部位感染效果更好。受纳入文献质量影响,未来需进行更多高质量研究对本研究结论加以验证。Objective:To systematically evaluate effect of chlorhexidine and povidone-iodine on preventing surgical site infection.Methods:Randomized controlled trials on preventing surgical site infection of chlorhexidine and povidone⁃iodine,were retrieved from the databases such as CNKI,Wanfang Data,VIP,PubMed,EMbase,The Cochrane Library and so on.The retrieval period was from the establishment of databases to 5 July,2020.After two researchers independently completed literature screening,data extraction and quality evaluation,RevMan 5.3 software was used for Meta analysis.Results:A total of 19 articles were included.Meta analysis results showed that total infection rate of surgical site[RR=0.67,95%CI(0.58,0.77),P<0.00001],infection rate of superficial surgical incisions[RR=0.54,95%CI(0.42,0.70),P<0.00001]and infection rate of deep surgical incision[RR=0.54,95%CI(0.33,0.88),P=0.01]of patients receiving chlorhexidine disinfection were lower than those of patients receiving povidone⁃iodine disinfection.Conclusions:Existing evidence shows that compared with povidone⁃iodine,chlorhexidine is more effective in preventing infections of surgical site.Due to the limited by quality of included literatures,more high⁃quality studies are needed to verify conclusions of this study in the future.

关 键 词：氯己定 聚维酮碘 消毒 感染 循证护理 系统评价 

分 类 号：R473.6[医药卫生—护理学]