生物光学成像技术在干细胞应用中的研究进展  

Advances in optical imaging technology for stem cell application

作　　者：周影 周春根 江滨[2] Zhou Ying;Zhou Chungen;Jiang Bin(Nanjing University of Chinese Medicine,Nanjing 210029,China;Nanjing Hospital of Chinese Medicine Affiliated to Nanjing University of Chinese Medicine,Nanjing 210022,China)

机构地区：[1]南京中医药大学,210029 [2]南京中医药大学附属南京中医院,210022

出　　处：《中华细胞与干细胞杂志（电子版）》2021年第3期189-192,共4页Chinese Journal of Cell and Stem Cell（Electronic Edition）

基　　金：江苏省卫生和计划生育委员会委科研课题(ZDB202002);江苏省研究生科研与实践创新计划(SJCX21_0747)。

摘　　要：干细胞目前已应用在多种疾病的治疗中,前景十分广阔,但干细胞存活、分布和迁移等具体机制仍未明确,需要通过长期有效、无副作用的干细胞示踪技术进一步研究。生物光学成像(OI)技术与干细胞相结合,操作简单、成像直观,并有高灵敏度和高特异性,可以实时、无创监测干细胞在动物活体内的生物学活动。本文就OI示踪技术的原理及其在干细胞应用中的研究进展做一综述。Recently,stem cell therapy has emerged as an effective therapeutic approach in various area,however,the specific mechanism of stem cell survival,distribution and migration remains unclear,which needs to be further studied by long-term effective stem cell tracer technology without any side effects.Bio-optical imaging technologycan detect biological activities in living animals in real time noninvasively,andit is simple in operation and intuitive in imaging with high sensitivity and specificity.This article reviews the fundamental of optical imaging(OI)tracer technique and its application in stem cell therapy.

关 键 词：干细胞 示踪 生物发光成像 荧光成像 近红外荧光成像 光声成像 光学层析成像 

分 类 号：Q63[生物学—生物物理学]