特布他林联合丙酸氟替卡松治疗慢性阻塞性肺疾病急性加重期的疗效及对肺功能的影响  

Efficacy of terbutaline combined with fluticasone propionate in the treatment of acute exacerbation of chronic obstructive pulmonary disease and its influence on pulmonary function

作　　者：张帅 ZHANG Shuai(Department of Respiratory and Critical Care Medicine,Foshan Fourth People’s Hospital,Foshan 528000,China)

机构地区：[1]佛山市第四人民医院呼吸与危重症医学科,528000

出　　处：《中国实用医药》2021年第20期123-125,共3页China Practical Medicine

摘　　要：目的探讨特布他林联合丙酸氟替卡松治疗慢性阻塞性肺疾病急性加重期(AECOPD)的疗效及对肺功能的影响。方法106例AECOPD患者按随机数字表法分为对照组与观察组,各53例。两组基础治疗保持一致,对照组使用丙酸氟替卡松治疗,观察组在对照组治疗基础上结合特布他林治疗。对比两组临床疗效、治疗前后肺功能指标及血气分析指标。结果观察组总有效率为98.11%显著高于对照组的86.79%,差异具有统计学意义(P<0.05)。治疗后,两组1秒用力呼气量(FEV1)、用力肺活量(FVC)、FEV1/FVC水平均高于本组治疗前,且观察组高于对照组,差异均具有统计学意义(P<0.05)。治疗后,两组动脉血氧分压(PaO_(2))水平均高于本组治疗前、动脉血二氧化碳分压(PaCO_(2))水平均低于本组治疗前,且观察组PaO_(2)水平为(10.86±0.71)kPa高于对照组的(9.71±0.65)kPa、PaCO_(2)水平为(6.35±0.54)kPa低于对照组的(7.44±0.61)kPa,差异均具有统计学意义(P<0.05)。结论特布他林联合丙酸氟替卡松治疗可进一步改善AECOPD患者的肺功能和血气分析指标,提高疗效。Objective To discuss the efficacy of terbutaline combined with fluticasone propionate in the treatment of acute exacerbation of chronic obstructive pulmonary disease(AECOPD)and its influence on pulmonary function.Methods A total of 106 AECOPD patients were divided into control group and observation group according to random numerical table,with 53 cases in each group.Both groups received basic therapy.The control group was also treated with fluticasone propionate,and the observation group was also treated with terbutaline based on the control group.The clinical efficacy,pulmonary function indicators and blood gas analysis indexes before and after treatment were compared between the two groups.Results The total effective rate 98.11%of the observation group was significantly higher than 86.79%of the control group,and the difference was statistically significant(P<0.05).After treatment,the forced expiratory volume in the first second(FEV1),forced vital capacity(FVC)and FEV1/FVC of the two groups were higher than those before treatment,and the observation group was higher than the control group.All the difference was statistically significant(P<0.05).After treatment,the arterial partial pressure of oxygen(PaO_(2))of the two groups was higher than that before treatment,and the arterial partial pressure of carbon dioxide(PaCO_(2))was lower than that before treatment;the PaO_(2)(10.86±0.71)kPa of the observation group was higher than(9.71±0.65)kPa of the control group,and PaCO_(2)(6.35±0.54)kPa of the observation group was lower than(7.44±0.61)kPa of the control group.All the difference was statistically significant(P<0.05).Conclusion Combination of terbutaline and fluticasone propionate can further improve the pulmonary function and blood gas analysis index of AECOPD patients,and improve their efficacy.

关 键 词：特布他林 丙酸氟替卡松 慢性阻塞性肺疾病 急性加重期 肺功能 

分 类 号：R563.9[医药卫生—呼吸系统]