急诊硝普钠治疗高血压并急性左心衰的疗效分析  

Efficacy analysis of sodium nitroprusside in emergency treatment of hypertension with acute left heart failure

作　　者：魏萍萍 李丽丽 WEI Ping-ping;LI Li-li(Fukuang General Hospital of Liaoning Health Industry Group,Fushun 113008,China)

机构地区：[1]辽宁省健康产业集团抚矿总医院,113008

出　　处：《中国实用医药》2021年第19期142-145,共4页China Practical Medicine

摘　　要：目的探讨急诊硝普钠治疗高血压并急性左心力衰竭(心衰)的临床效果。方法96例高血压并急性左心衰患者,随机分为对照组(50例)与观察组(46例)。对照组给予常规治疗措施治疗,观察组在常规治疗基础上增加硝普钠治疗。比较两组患者治疗效果、不良反应发生情况以及治疗前后呼吸频率、心率、血压、血气分析指标。结果观察组治疗总有效率95.7%高于对照组的82.0%,差异具有统计学意义(P<0.05)。治疗后,观察组呼吸频率(20.9±1.2)次/min、心率(90.1±3.7)次/min、收缩压(109.5±6.3)mm Hg(1 mm Hg=0.133 kPa)、舒张压(66.7±3.9)mm Hg均优于对照组的(23.7±1.7)次/min、(114.4±5.3)次/min、(125.1±10.7)mm Hg、(84.2±5.7)mm Hg,差异均具有统计学意义(P<0.05)。治疗后,观察组血氧饱和度(SaO_(2))为(94.01±.772)%、动脉血氧分压(PaO_(2))为(87.22±7.93)mm Hg,均高于对照组的(84.17±2.86)%、(71.13±8.01)mm Hg,差异具有统计学意义(P<0.05)。两组动脉血二氧化碳分压(PaCO_(2))、碳酸氢根离子(HCO_(3)^(-))水平比较,差异均无统计学意义(P>0.05)。两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论硝普钠治疗高血压并急性左心衰可有效稳定患者生命体征,提升治疗效果,安全性和临床应用价值高。Objective To discuss the clinical effect of sodium nitroprusside in emergency treatment of hypertension with acute left heart failure.Methods A total of 96 cases of hypertension with acute left heart failure were randomly divided into control group(50 cases)and observation group(46 cases).The control group was treated with conventional therapy,and the observation group was treated with sodium nitroprusside based on conventional therapy.The therapeutic effect,occurrence of adverse reactions,respiratory rate,heart rate,blood pressure and blood gas analysis indexes before and after treatment were compared between the two groups.Results The total effective rate 95.7%of the observation group was higher than 82.0%of the control group,and the difference was statistically significant(P<0.05).After treatment,the respiratory rate(20.9±1.2)times/min,heart rate(90.1±3.7)beats/min,systolic blood pressure(109.5±6.3)mm Hg(1 mm Hg=0.133 kPa)and diastolic blood pressure(66.7±3.9)mm Hg of the observation group were better than(23.7±1.7)times/min,(114.4±5.3)beats/min,(125.1±10.7)mm Hg and(84.2±5.7)mm Hg of the control group,and the difference was statistically significant(P<0.05).After treatment,the arterial oxygen saturation(SaO2)(94.01±.772)%and arterial partial pressure of oxygen(PaO2)(87.22±7.93)mm Hg of the observation group were higher than(84.17±2.86)%and(71.13±8.01)mm Hg of the control group,and the difference was statistically significant(P<0.05).There was no statistically significant difference in arterial partial pressure of carbon dioxide(PaCO2)and bicarbonate ion(HCO3-)between the two groups(P>0.05).There was no statistically significant difference in incidence of adverse reactions between the two groups(P>0.05).Conclusion Sodium nitroprusside has high clinical value in the treatment of hypertension with acute left heart failure,and it can effectively stable vital signs and improve the treatment effect with high safety.

关 键 词：急诊 硝普钠 高血压 急性左心力衰竭 

分 类 号：R541.6[医药卫生—心血管疾病] R544.1[医药卫生—内科学]