长疗程甲巯咪唑片治疗Graves病的疗效及不良反应发生情况研究  

Efficacy and occurrence of adverse reactions of long-term thiamazole tablets in the treatment of toxic diffuse goiter

作　　者：杨雪梅 YANG Xue-mei(Gaizhou Central Hospital,Yingkou 115200,China)

机构地区：[1]盖州市中心医院,115200

出　　处：《中国实用医药》2021年第19期145-147,共3页China Practical Medicine

摘　　要：目的探讨长疗程甲巯咪唑片治疗弥漫性毒性甲状腺肿(Graves病)的疗效及不良反应发生情况。方法100例Graves病患者,随机分为常规剂量组与低剂量组,各50例。常规剂量组采用常规剂量的长疗程甲巯咪唑片治疗,低剂量组采用采用低剂量的长疗程甲巯咪唑片治疗。比较两组治疗效果、不良反应发生率。结果低剂量组治疗总有效率为90.00%,与常规剂量组的92.00%比较,差异无统计学意义(P>0.05)。低剂量组不良反应发生率8.00%(4/50)低于常规剂量组24.00%的(12/50),差异有统计学意义(P<0.05)。结论长疗程甲巯咪唑片治疗Graves病的疗效确切,其中,采取低剂量的安全性高。Objective To discuss the efficacy and occurrence of adverse reactions of long-term thiamazole tablets in the treatment of toxic diffuse goiter(Graves disease).Methods A total of 100 patients with Graves disease were randomly divided into conventional dose group and low-dose group,with 50 cases in each group.Conventional dose group was treated with conventional dose of long-term thiamazole tablets,and low-dose group was treated with low-dose of long-term thiamazole tablets.The therapeutic effect and occurrence of adverse reactions were compared between the two groups.Results The total effective rate of low-dose group was 90.00%,which had no statistically significant difference compared with 92.00%of conventional dose group(P>0.05).The incidence of adverse reactions 8.00%(4/50)of low-dose group was lower than 24.00%(12/50)of low-dose group,and the difference was statistically significant(P<0.05).Conclusion Long-term thiamazole tablets has certain efficacy in the treatment of toxic diffuse goiter,and the treatment with low dose is safe.

关 键 词：甲巯咪唑片 弥漫性毒性甲状腺肿 长疗程 不良反应 

分 类 号：R581.1[医药卫生—内分泌]