卤素官能团化的[1,2,4]三嗪并[5,6-b]吲哚-3-硫醇类化合物的合成  

Synthesis of halo-functionalized[1,2,4]triazino[5,6-b]indole-3-thiols

作　　者：王泓雪 纪铭 黄文远 李阳[1] 高文涛[1] 张红[1] WANG Hong-xue;JI Ming;HUANG Wen-yuan;LI Yang;GAO Wen-tao;ZHANG Hong(College of Chemistry and Materials Engineering,Bohai University,Jinzhou 121000,China;Liaoyang Bureau of Quality and Technical Supervision,Liaoyang 111099,China;Fuxin Institute For Drug Control,Fuxin 123000,China)

机构地区：[1]渤海大学化学与材料工程学院,辽宁锦州121000 [2]辽阳市质量技术监督局,辽宁辽阳111099 [3]阜新市药品检验所,辽宁阜新123000

出　　处：《化学研究与应用》2021年第7期1360-1367,共8页Chemical Research and Application

基　　金：辽宁省教育厅项目(LQ2019006)资助;辽宁省科技厅博士启动项目(2019-BS-004)资助。

摘　　要：本文利用各种卤代的靛红为底物,与氨基硫脲在水-二氧六环(V/V,5∶1)混合溶剂为反应介质,K_(2)CO_(3)为碱条件下,进行缩合反应,有效合成了一系列卤素官能团化的[1,2,4]三嗪并[5,6-b]吲哚-3-硫醇类化合物。所合成的目标化合物未见文献报道,其结构均已通过谱图(^(1)H-NMR、^(13)C-NMR和MS)数据和元素分析得以确认。In this work,a facile and general synthesis of a series of structurally intriguing halo-functionalized[1,2,4]triazino[5,6-b]indole-3-thiols had been achieved in good yields through the condensation reaction of various halogenated isatins with thiosemicarbazide using H_(2)O-dioxane(V/V,5∶1)solvent system as reaction medium with the presence of K_(2)CO_(3)as base.The molecular structures of these newly synthesized products were confirmed by spectral data(^(1)H-NMR,^(13)C-NMR and MS)and elemental analyses.

关 键 词：卤取代 [1 2 4]三嗪并[5 6-b]吲哚 缩合反应 靛红 氨基硫脲 

分 类 号：O625[理学—有机化学]