天然混源萜Chromazonarol的合成及生物活性研究进展  

Advance in the Synthesis and Biological Activities of the Natural Meroterpenoid Chromazonarol

作　　者：李圣坤 王侠 LI Shengkun;WANG Xia(Key Laboratory of Green Pesticide and Agricultural Bioengineering,Ministry of Education,Guizhou University,Guiyang 550025,China;The Center for Research and Development of Fine Chemicals,Guizhou University,Guiyang 550025,China;College of Plant Protection,Nanjing Agricultural University,Nanjing 210095,China)

机构地区：[1]贵州大学教育部绿色农药与农业生物工程重点实验室,贵州贵阳550025 [2]贵州大学精细化工研究开发中心,贵州贵阳550025 [3]南京农业大学植物保护学院,江苏南京210095

出　　处：《贵州大学学报（自然科学版）》2021年第4期1-10,共10页Journal of Guizhou University:Natural Sciences

基　　金：国家自然科学基金资助项目(21772094,21977049)。

摘　　要：Drimane氢醌是来源于萜类和聚酮化合物途径的天然产物,它们通常具有稠环结构并显示多种重要的生物活性。Chromazonarol含有特征性的6-6-6-6四环骨架,且具有抗肿瘤、抗真菌、杀藻等重要生物活性,引起了众多有机合成化学家和药物化学家的关注。本文综述了天然产物Chromazonarol及异构体的分离,生物活性和合成进展。Drimane quinone/hydroquinone sesquiterpenes are natural products of mixed biosynthetic origin which are derived from both terpenoid and polyketide pathways.They usually possess fused polycyclic systems and display multiple interesting biological activities.Chromazonarol features a characteristic 6-6-6-6 tetracyclic framework,exhibiting antitumor,algicidal and antifungal activities.Chromazonarol has attracted a great deal of attentions from both synthetic organic chemists and medicinal chemists.This review summarizes the isolation,biological activities and synthesis of chromazonarol.

关 键 词：Drimane氢醌 生物活性 全合成 

分 类 号：O629.6[理学—有机化学]