阿奇霉素联合中药免疫方剂治疗小儿肺炎支原体感染的疗效观察  

Clinical Efficacy Observation of Azithromycin Combined with Chinese Medicine Immune-enhancing Formulae in the Treatment of Mycoplasma Pneumoniae Infection in Children

作　　者：马永梅[1] 任晓红[2] 马春梅[3] 穆亚宁[1] MA Yong-Mei;REN Xiao-Hong;MA Chun-Mei;MU Ya-Ning(Third Pediatrics Dept.,Baoji Maternal and Child Health Hospital,Baoji 721000 Shaanxi,China;Fifth Pediatrics Dept.,Baoji Maternal and Child Health Hospital,Baoji 721000 Shaanxi,China;First Dept.of Internal Medicine,Baoji Rehabilitation Hospital,Baoji 721000 Shaanxi,China)

机构地区：[1]宝鸡市妇幼保健院儿三科,陕西宝鸡721000 [2]宝鸡市妇幼保健院儿五科,陕西宝鸡721000 [3]宝鸡市康复医院内一科,陕西宝鸡721000

出　　处：《广州中医药大学学报》2021年第7期1351-1356,共6页Journal of Guangzhou University of Traditional Chinese Medicine

摘　　要：【目的】探究阿奇霉素联合中药免疫方剂在治疗小儿肺炎支原体感染中的疗效,并分析其对患儿免疫指标的影响。【方法】将102例肺炎支原体感染且病程在1周以上的患儿随机分为西药组、中药组和联合组3组,每组各34例。西药组接受常规阿奇霉素治疗,中药组接受中药免疫方剂颗粒剂治疗,联合组接受阿奇霉素联合中药免疫方剂颗粒剂治疗。1周为1个疗程,连续治疗2个疗程。观察3组患儿治疗前后免疫指标[免疫球蛋白A(IgA)、免疫球蛋白G(IgG)、免疫球蛋白M(IgM)]和炎性指标[C反应蛋白(CRP)、白细胞介素6(IL-6)]的变化情况,比较3组患儿临床症状(退热时间、咳嗽消失时间、肺部湿罗音消失时间、X线吸收消散时间)改善时间,并评价3组患儿的临床疗效。【结果】(1)治疗2个疗程后,联合组的总有效率为97.06%(33/34),西药组为76.47%(26/34),中药组为85.29%(29/34),组间比较,联合组的疗效明显优于西药组(P<0.05),同时也有优于中药组的趋势,但差异无统计学意义(P>0.05);而中药组的疗效有优于西药组的趋势,但差异无统计学意义(P>0.05)。(2)联合组患儿的退热时间、咳嗽消失时间、肺部湿罗音消失时间、X线吸收消散时间均短于西药组和中药组(P<0.05),且中药组患儿的退热时间、咳嗽消失时间、肺部湿罗音消失时间、X线吸收消散时间也短于西药组(P<0.05)。(3)治疗后,3组患儿的IgA、IgG及IgM水平均较治疗前明显升高(P<0.05),组间比较,联合组的IgA、IgG及IgM水平有高于西药组和中药组趋势,中药组有高于西药组趋势,但差异均无统计学意义(P>0.05)。(4)治疗后,3组患儿的CRP、IL-6水平均较治疗前明显下降(P<0.05),组间比较,联合组的CRP、IL-6水平均低于西药组和中药组(P<0.05),且中药组也有低于西药组趋势,但差异均无统计学意义(P>0.05)。【结论】阿奇霉素联合中药免疫方剂对肺炎支原体感染中后期患儿�Objective To investigate the clinical efficacy of Azithromycin combined with Immune-enhancing Formula in the treatment of mycoplasma pneumoniae infection in children,and to observe the impact of the therapy on the immune indicators of children.Methods A total of 102 children with mycoplasma pneumoniae infection for over one week were randomly divided into 3 groups,namely western medicine group,Chinese medicine group and the combined therapy group,and each group had 34 cases.The western medicine group was treated with Azithromycin,Chinese medicine group was treated with granules of Chinese medicine immuneenhancing formulae,and the combined therapy group was treated with Azithromycin combined with granules of Chinese medicine immune-enhancing formulae.One week constituted a course of treatment,and the treatment for the two groups lasted for two courses.The clinical outcomes covered pre-and post-treatment immune function indicators of immunoglobulin A(IgA),immunoglobulin G(IgG)and immunoglobulin M(IgM),and inflammatory indexes of C-reactive protein(CRP)and interleukin 6(IL-6),time for the relief of clinical symptoms including antipyretic time,time for cough clearing up,time for lung wet rales disappearance,time for the absorption and dissipation of inflammation showed by X-ray imaging,and the curative effect.Results(1)After two courses of treatment,the total effective rate of the combined therapy group was 97.06%(33/34),and that of western medicine group was 76.47%(26/34)and was 85.29%(29/34)in Chinese medicine group.The intergroup comparison showed that the efficacy in the combined therapy group was obviously superior to that in the western medicine group(P<0.05),and tended to be stronger than that in the Chinese medicine group,but the difference was insignificant(P>0.05).The efficacy in the Chinese medicine group tended to be stronger than that in the western medicine group,but the difference was either insignificant(P>0.05).(2)The antipyretic time,time for cough clearing up,time for lung wet rales disappearance,a

关 键 词：阿奇霉素 中药免疫方剂 肺炎支原体感染 小儿 免疫功能 炎性指标 

分 类 号：R256.11[医药卫生—中医内科学] R969.4[医药卫生—中医学]