补肾类中药改善子宫内膜容受性相关指标研究述评  

Review of Relevant Endometrial Receptivity Parameters Improved by Kidney-tonifying Chinese Medicine

作　　者：蒋晓梅[1] 李贺月 徐海霞[1] 张尊胜 李虹[1] 张育斌 马力凤 李林霞 JIANG Xiao-Mei;LI He-Yue;XU Hai-Xia;ZHANG Zun-Sheng;LI Hong;ZHANG Yu-Bin;MA Li-Feng;LI Lin-Xia(Dept.of Gynecology and Obstetrics,the Seventh People’s Hospital Affiliated to Shanghai University of Traditional Chinese Medicine,Shanghai 202137,China)

机构地区：[1]上海中医药大学附属第七人民医院妇产科,上海202137

出　　处：《广州中医药大学学报》2021年第7期1531-1536,共6页Journal of Guangzhou University of Traditional Chinese Medicine

基　　金：浦东新区卫生系统高峰高原学科建设资助项目(编号:PDZY-2018-0608)。

摘　　要：子宫内膜容受性是影响辅助生殖技术治疗不孕症能否取得妊娠成功的因素之一。补肾类中药可通过调整阴阳、益精补髓提高子宫内膜的容受性。通过综述补肾类中药对子宫内膜容受性相关的超声学指标、组织形态学指标、细胞间黏附分子、细胞因子、调节基因等的影响,认为补肾类中药提高子宫内膜容受性可能与改善子宫内膜厚度、子宫内膜类型、子宫内膜血流等超声学指标及改善组织形态学结构、胞饮突等组织形态学指标,促进子宫内膜整合素β3蛋白、白血病抑制因子蛋白及mRNA的表达,提高血管内前列腺素水平及子宫内膜HOXA10水平等有关。综述补肾类中药改善子宫内膜容受性的作用机理,可为提高中西医结合治疗不孕症患者的疗效提供参考。Endometrial receptivity is one of the influencing factors for the successful pregnancy during the treatment of infertility with assisted reproductive technology.Kidney-tonifying Chinese Medicine has the actions of regulating the balance of yin and yang,nourishing essence and bone marrow,and can enhance the endometrial receptivity.In this article,we reviewed the influences of kidney-tonifying Chinese Medicine on the relevant endometrial receptivity parameters of ultrasonic indexes,histomorphology features,intercellular adhesion molecules,cytokines,regulatory genes,etc..It is considered that the mechanism of kidney-tonifying Chinese medicine in increasing endometrial receptivity is probably related with the improvement of ultrasonic indexes of endometrial thickness,endometrium types,and endometrial blood flow,with the improvement of histomorphology features of morphological structure and pinopodes,with the increase of protein and mRNA expression levels of endometrial integrinβ3 and leukemia inhibitory factor,and with the enhancement of vascular prostaglandin and endometrial HOXA10 levels.The therapeutic mechanism of kidney-tonifying Chinese medicine in improving the endometrial receptivity was reviewed,aiming at supply reference for the increase of therapeutic efficacy of integrated Chinese medicine and western medicine in treating infertility.

关 键 词：补肾类中药 不孕症 子宫内膜容受性 辅助生殖技术 超声学指标 细胞间黏附分子 

分 类 号：R271.14[医药卫生—中医妇科学]