有机催化不对称合成3,4-二氢吡喃-2-酮和3,4-二氢吡啶-2-酮衍生物研究进展  

Recent Advances in Organocatalytic Asymmetric Synthesis of 3,4-Dihydropyran-2-ones and 3,4-Dihydropyridin-2-ones

作　　者：底慧明 刘云婷 马艳榕 杨鑫悦 金辉[1] 张立新[1] Di Huiming;Liu Yunting;Ma Yanrong;Yang Xinyue;Jin Hui;Zhang Lixin(Shenyang Key Laboratory of Targeted Pesticides,Liaoning Key Laboratory of Green Functional Molecular Design and Development,Institute of Functional Molecules,Shenyang University of Chemical Technology,Shenyang 110142)

机构地区：[1]沈阳化工大学功能分子研究所辽宁省绿色功能分子设计与开发重点实验室沈阳市靶向农药重点实验室,沈阳110142

出　　处：《有机化学》2021年第6期2228-2248,共21页Chinese Journal of Organic Chemistry

基　　金：辽宁省教育厅科学研究(No.LQ2020025);南宁市科学研究与技术开发计划(No.20201043)资助项目。

摘　　要：3,4-二氢吡喃-2-酮和3,4-二氢吡啶-2-酮结构广泛存在于多种天然产物和具有药理活性的分子中,因此高效合成手性3,4-二氢吡喃-2酮和3,4-二氢吡啶-2酮受到越来越多药物化学和有机化学研究者的关注.近年来有机小分子催化的不对称反应已成为构建手性杂环化合物的有效方法.综述了自2003年至今有机小分子催化的不对称反应合成手性3,4-二氢吡喃酮和3,4-二氢吡啶酮衍生物的研究进展,并根据不同的催化剂类型及反应机理进行分类讨论.3,4-Dihydropyranone and 3,4-dihydropyridinone substructures are widely found in a variety of natural products and pharmacologically active molecules, so the efficient synthesis of chiral 3,4-dihydropyranones and 3,4-dihydropyridinones has received more and more attention from pharmaceutical chemists and organic chemists. In recent years, organocatalytic asymmetric reaction has become an efficient synthetic method for the construction of chiral heterocyclic compounds. In this review, the remarkable progress and advances in organocatalytic asymmetric reactions for the synthesis of 3,4-dihydropyranones and 3,4-dihydropyridinones from 2003 to 2020 are summarized and discussed based on the different types of organocatalysts and reaction mechanisms.

关 键 词：有机催化 不对称催化 3 4-二氢吡喃酮 3 4-二氢吡啶酮 

分 类 号：O626[理学—有机化学]