《千金》温脾丸煎剂联合乌灵胶囊治疗不寐厥阴实证患者的临床观察  

Clinical Observation on Invaluable Prescriptions Wenpi Pills Decoction Combined with Wuling Capsules for Treatment of Insomnia with Jueyin Excess Syndrome

作　　者：郭雪宜 肖纯 闻思齐 GUO Xue-Yi;XIAO Chun;WEN Si-Qi(Shenzhen Baoan Traditional Chinese Medicine Hospital Group,the Affiliated Hospital of Guangzhou University of Chinese Medicine,Shenzhen 518100 Guangdong,China;Graduate School of Guangzhou University of Chinese Medicine,Guangzhou 510405 Guangdong,China)

机构地区：[1]广州中医药大学附属宝安中医院深圳市宝安中医院(集团),广东深圳518100 [2]广州中医药大学研究生院,广东广州510405

出　　处：《广州中医药大学学报》2021年第8期1577-1582,共6页Journal of Guangzhou University of Traditional Chinese Medicine

基　　金：广东省名中医传承工作室(粤中医办函[2020]1号)。

摘　　要：【目的】观察《千金》温脾丸煎剂联合乌灵胶囊治疗不寐厥阴实证患者的临床疗效。【方法】将120例不寐厥阴实证患者随机分为联合组、温脾组和乌灵组,每组各40例。联合组给予口服《千金》温脾丸煎剂联合乌灵胶囊治疗,温脾组给予口服《千金》温脾丸煎剂治疗,乌灵组给予口服乌灵胶囊治疗,疗程为4周。观察3组患者治疗前后各项中医证候评分及各项睡眠障碍评定量表(SDRS)评分的变化情况,并评价3组患者的临床疗效。【结果】(1)治疗期间,3组不寐厥阴实证患者共脱落11例(包括联合组4例、温脾组4例和乌灵组3例),最终纳入109例,其中联合组36例,温脾组36例,乌灵组37例。(2)治疗4周后,联合组、温脾组、乌灵组的总有效率分别为97.22%(35/36)、88.89%(32/36)、67.57%(25/37),3组间比较,联合组的临床疗效明显优于温脾组和乌灵组,差异均有统计学意义(P<0.05)。(3)治疗后,3组患者的各项中医证候评分均较治疗前明显改善(P<0.05),且联合组对各项中医证候评分的改善作用均明显优于温脾组和乌灵组,差异均有统计学意义(P<0.05)。(4)治疗后,3组患者的具体睡眠情况、各段失眠情况、醒后不适感等各项SDRS评分及总分均较治疗前明显改善(P<0.05),且联合组对各项SDRS评分及总分的改善作用均明显优于温脾组和乌灵组,差异均有统计学意义(P<0.05)。【结论】在改善不寐厥阴实证患者的中医证候和SDRS评分方面,《千金》温脾丸煎剂联合乌灵胶囊的治疗效果优于单用《千金》温脾丸煎剂和单用乌灵胶囊。Objective To observe the therapeutic effect of Invaluable Prescriptions Wenpi Pills Decoction combined with Wuling Capsules for the treatment of insomnia with Jueyin excess syndrome. Methods A total of 120 insomnia patients were randomized into combined therapy group,Wenpi Pills group and Wuling Capsules group,and each group had 40 cases. The combined therapy group was treated with Invaluable Prescriptions Wenpi Pills Decoction combined with Wuling Capsules orally, Wenpi Pills group was treated with Invaluable Prescriptions Wenpi Pills Decoction orally,and Wuling Capsules group was treated with Wuling Capsules orally. The course of treatment for the 3 groups lasted 4 weeks. Before and after treatment,the traditional Chinese medicine(TCM)syndrome scores and the scores of sleep dysfunction rating scale(SDRS)in the three groups were examined. Meanwhile, the clinical efficacy in the 3 groups was also evaluated. Results(1)During the treatment,11 cases(4 from combined therapy group,4 from Wenpi Pills group and 3 from Wuling Capsules group)dropped out,and finally a total of109 cases,36 of combined therapy group,36 of Wenpi Pills group and 37 of Wuling Capsules group completed the trial.(2)After 4 weeks of treatment,the overall effective rate in the combined therapy group,Wenpi Pills group and Wuling Capsules group was 97.22%(35/36), 88.89%(32/36), 67.57%(25/37), respectively. The intergroup showed that the combined therapy group had stronger efficacy than the other two groups, and the difference was statistically significant(P<0.05).(3)After treatment,TCM syndrome scores in the 3 groups were obviously improved in comparison with those before treatment(P<0.05),and the combined therapy group had stronger efficacy on improving the syndrome scores than the other two groups,the difference being statistically significant(P<0.05).(4)After treatment,the scores of sleep status,various stages of insomnia,and discomforts after awakening as well as overall SDRS scores in the 3 groups were obviously improved in comparison with those

关 键 词：不寐 厥阴实证 《千金》温脾丸煎剂 乌灵胶囊 中医证候评分 睡眠障碍评定量表(SDRS)评分 

分 类 号：R256.23[医药卫生—中医内科学]