加味四逆散联合隔盐灸治疗肝郁脾虚证腹泻型肠易激综合征的疗效观察  

Clinical Observation of Jiawei Sini Powder(加味四逆散)Combined with Salt Partitioned Moxibust ion on Diarrhea Predominant Irritable Bowel Syndrome of Liver Depression and Spleen Deficiency Syndrome

作　　者：雷彪 冯文哲 石鹏 牛魁 柴小琴 LEI Biao;FENG Wen-zhe;SHI Peng;NIU Kui;CHAI Xiao-qin(Affiliated Hospital of Shaanxi University of Traditional Chinese Medicine,Xianyang Shaanxi 712000,China)

机构地区：[1]陕西中医药大学附属医院,陕西咸阳712000

出　　处：《中医药导报》2021年第6期95-98,共4页Guiding Journal of Traditional Chinese Medicine and Pharmacy

基　　金：陕西省中医药管理局课题(JCPT050);陕西中医药大学课题(2016PY02)。

摘　　要：目的:观察加味四逆散联合隔盐灸治疗肝郁脾虚证腹泻型肠易激综合征(IBS-D)的临床疗效。方法:将67例肝郁脾虚证IBS-D患者随机分为对照组34例和治疗组33例。对照组患者予匹维溴铵片口服,治疗组患者予加味四逆散口服及隔盐灸治疗。两组患者均连续治疗4周。观察两组患者治疗前后临床症状评分、IBS-D患者生活质量专用量表(IBS-QOL)评分、血清白介素-6(IL-6)的变化,并评判两组患者治疗后的临床疗效。结果:治疗组总有效率为93.94%(31/33),对照组总有效率为67.65%(23/34),治疗组明显高于对照组(P<0.05)。治疗4周后,两组患者腹痛、腹泻、大便次数、情志、神疲乏力、烦躁易怒、胁肋胀痛评分均较治疗前降低,且治疗组患者评分均低于对照组,差异均有统计学意义(P<0.05);两组患者血清IL-6含量均较治疗前明显降低,且治疗组患者血清IL-6含量明显低于对照组,差异均有统计学意义(P<0.05);两组患者IBS-QOL评分较治疗前均升高,且治疗组患者IBS-QOL评分明显高于对照组,差异均有统计学意义(P<0.05)。结论:加味四逆散联合隔盐灸治疗肝郁脾虚证IBS-D有较好临床疗效。Objective:To observe the clinical effect of Jiawei Sini Powder combined with salt partitioned moxibustion on diarrhea predominant irritable bowel syndrome(IBS-D)of liver depression and spleen deficiency syndrome.Methods:Totally 67 IBS-D patients with liver depression and spleen deficiency syndrome were randomly divided into control group(n=34)and treatment group(n=33).Patients were treated by pinaverium bromide tablets orally in the control group,and Jiawei Sini Powder orally and salt partitioned moxibustion in treatment group.Patients were treated for four weeks in two groups.The clinical symptom score,IBS-QOL score and serum IL-6 were observed before and after treatment in the two groups.And the clinical efficacy was evaluated in two groups.Results:The total effective rate was 93.94%(31/33)in treatment group and 67.65%(23/34)in control group,and the treatment group showed higher total effective rate than control group(P<0.05).Compared with before treatment,the abdominal pain score,diarrhea score,stool frequency score,emotion score,fatigue score,irritability score and distending pain of flank score decreased in two groups after treatment of four weeks,and the treatment group showed lower above scores than control group after treatment,with statistically significant differences(P<0.05);Compared with before treatment,the serum IL-6 decreased in two groups after treatment,and the treatment group showed lower serum IL-6 than control group after treatment,with statistically significant differences(P<0.05);Compared with before treatment,the BS-QOL scores increased in two groups after treatment,and the treatment group showed higher BS-QOL scores than control group after treatment,with statistically significant differences(P<0.05).Conclusion:Jiawei Sini Powder combined with salt partitioned moxibustion shows good clinical efficacy on IBS-D patients with liver depression and spleen deficiency syndrome.

关 键 词：肠易激综合征 肝郁脾虚证 四逆散 隔盐灸 匹维溴铵片 

分 类 号：R256.34[医药卫生—中医内科学]