归肾丸加味治疗男性不育症肾阴亏虚证的疗效观察  

Efficacy of Guishen Pill(归肾丸)Treating Male Infertility with Syndrome of Kidney Yin Deficiency

作　　者：张自强 孙永康 刘建涛 杨万期 ZHANG Ziqiang;SUN Yongkang;LIU Jiantao;YANG Wanqi(Baodi Clinical College of Tianjin Medical University,Tianjin 301800,China)

机构地区：[1]天津医科大学宝坻临床学院中医科,天津301800

出　　处：《辽宁中医杂志》2021年第5期84-87,共4页Liaoning Journal of Traditional Chinese Medicine

基　　金：天津市卫生计生委中医,中西医结合科研专项课题(2015151)。

摘　　要：目的探讨归肾丸加味治疗男性不育症肾阴亏虚证的临床疗效以及对血清促卵泡生成素(FSH)、促黄体生成激素(LH)、泌乳素(PRL)和精浆中超氧化物歧化酶(SOD)和丙二醛(MDA)水平的影响。方法该研究筛选男性不育症患者96例作为研究对象,按随机数字表法分为对照组和观察组,各48例。对照组患者接受辅酶Q10胶囊,10 mg/次,口服,3次/d。观察组在对照组治疗基础上给予归肾丸加味治疗,1剂/d, 2次/d。两组连续治疗3个月。比较两组患者的精液质量、肾阴亏虚证症状评分、临床疗效、血清FSH、LH、PRL以及精浆中SOD和MDA水平。结果与对照组比较,治疗后观察组患者的精子计数、精子活力、正常形态精子率、精子活率明显高于对照组,精液液化时间和肾阴亏虚证症状评分明显低于对照组(P<0.01);观察组的总有效率显著多于对照组(P<0.05);与对照组比较,治疗后观察组患者的血清FSH、LH、PRL明显高于对照组(P<0.01);与对照组比较,治疗后观察组精浆中SOD水平明显高于对照组,MDA水平明显低于对照组(P<0.01)。结论归肾丸加味治疗男性不育症肾阴亏虚证的临床疗效明显,改善生殖激素水平及氧化应激可能与其作用有关。Objective To investigate the efficacy of Guishen Pill(归肾丸) treating male infertility and its effect on levels of follicle-stimulating hormone(FSH),luteinizing hormone(LH) and prolactin(PRL) in the serum and levels of superoxide dismutase(SOD) and malondialdehyde(MDA) in the seminal fluid.Methods Ninety-six male infertility patients were selected as the research objects and divided into control group and observation group with 48 cases in each group according to the random number table method.The control group orally received Coenzyme Q10 Capsule(10 mg/time and 3 times/d).On the basis of treatment in the control group, the observation group was given with Guishen Pill(1 dose per day and 2 times/d).Both groups were treated continuously for 3 months.The semen quality, scores of symptoms of syndrome of kidney Yin deficiency, the clinical efficacy, serum levels of FSH,LH and PRL and levels of SOD and MDA in the seminal fluid were compared between the two groups.Results Compared with the control group, the sperm count, sperm motility, normal morphology sperm rate and sperm motility rate of the observation group were significantly higher, while the semen liquefaction time and scores of symptoms of syndrome of kidney Yin deficiency were significantly lower than those of the control group(P<0.01).The total effective rate of the observation group was significantly higher than that of the control group(P<0.05).Compared with those of the control group, the serum levels of FSH,LH and PRL in the observation group were significantly higher than those in the control group after treatment(P<0.01).Compared with that of the control group, the level of SOD in the seminal fluid of the observation group was significantly higher and MDA was significantly lower than that of the control group after treatment(P<0.01).Conclusion The efficacy of Guishen Pill in the treatment of male infertility with syndrome of kidney Yin deficiency is significant which may be related with regulation of reproductive hormone and oxidative stress.

关 键 词：男性不育症 归肾丸 肾阴亏虚证 生殖激素 氧化应激 

分 类 号：R698.2[医药卫生—泌尿科学]