健脾补肾温阳方治疗老年糖尿病肾病综合征的疗效及对中医证候评分、血肌酐、尿素氮指标的影响  

Therapeutic Effect of Jianpi Bushen Wenyang Formula(健脾补肾温阳方)on Senile Diabetic Nephropathy Syndrome and Its Influence on TCM Syndrome Score,SCr and BUN

作　　者：张曦旭 张珊珊[2] 代玉 杨潇[1] 江红[1] 王永[1] ZHANG Xixu;ZHANG Shanshan;DAI Yu;YANG Xiao;JIANG Hong;WANG Yong(The Second Affiliated Hospital of Liaoning University of Traditional Chinese Medicine,Shenyang 110034,Liaoning,China;Liaoning Provincial Corps Hospital of Chinese People's Aremed Police Force,Shenyang 110034,Liaoning,China;Tieling Hospital of traditional Chinese Medicine,Tieling 112000,Liaoning,China)

机构地区：[1]辽宁中医药大学附属第二医院,辽宁沈阳110034 [2]武警辽宁省总队医院,辽宁沈阳110034 [3]铁岭市中医医院,辽宁铁岭112000

出　　处：《辽宁中医杂志》2021年第5期130-132,共3页Liaoning Journal of Traditional Chinese Medicine

摘　　要：目的探析健脾补肾温阳方在老年糖尿病肾病综合征患者中的治疗效果,分析该方对中医证候评分、血肌酐(SCr)、尿素氮(BUN)指标的影响。方法选取该院2019年2月—2020年2月收治的82例老年糖尿病肾病综合征患者,根据不同疗法将其分为A组与B组,每组41例,A组予以前列地尔治疗,B组予以前列地尔联合健脾补肾温阳方治疗,对比两组患者的中医证候评分、临床疗效、肾功能指标(SCr、BUN)、血糖水平(空腹血糖、餐后2 h血糖、糖化血红蛋白数)以及不良反应发生情况(恶心、头晕、腹泻、皮疹、发热)。结果 B组治疗后的中医证候评分(12.32±2.18)分,低于A组(15.74±2.71)分,P<0.05;B组的总有效率(90.24%,37/41)高于A组(75.61%,31/41),P<0.05;B组治疗后的SCr、BUN水平(141.16±25.01)μmol/L、(8.03±3.99)mmol/L均低于A组(175.33±26.82)μmol/L、(10.15±4.31)mmol/L,P<0.05;B组治疗后的空腹血糖、餐后2h血糖、糖化血红蛋白水平(7.15±1.85)mmol/L、(8.03±1.74)mmol/L、(6.38±1.16)%均低于A组(8.22±2.03)mmol/L、(10.67±2.16)mmol/L、(7.52±1.23)%,P<0.05;B组的不良反应发生率(12.20%,5/41)与A组(9.76%,4/41)相近,P>0.05。结论健脾补肾温阳方在老年糖尿病肾病综合征患者中的治疗效果显著,可快速缓解患者的临床症状,改善肾功能指标,降低血糖水平,且与单纯西药治疗相比未新增不良反应,值得临床推行。Objective To explore the therapeutic effect of Jianpi Bushen Wenyang Formula(健脾补肾温阳方) in the elderly patients with diabetic nephropathy syndrome and analyze its influence on TCM syndrome score, blood creatinine(SCr) and urea nitrogen(BUN).Methods A total of 82 cases of senile diabetic nephrotic syndrome admitted to our hospital from February 2019 to February 2020 were divided into group A and group B according to different therapies, 41 cases in each group.Group A was treated with alprostadil and group B was treated with alprostadil combined with Jianpi Bushen Wenyang Formula.The TCM syndrome score, clinical effect, renal function indexes(SCr, BUN) and blood glucose levels of the two groups were compared.Fasting blood glucose, 2 hours postprandial blood glucose, glycosylated hemoglobin number) and adverse reactions(nausea, dizziness, diarrhea, rash, fever) were observed.Results After treatment, the TCM syndrome score [(12.32±2.18)points] in group B was lower than that in group A[(15.74±2.71)points](P<0.05).The total effective rate(90.24%,37/41) in group B was higher than that in group A(75.61%,31/41)(P<0.05).The levels of SCr and BUN[(141.16±25.01)μmol/L,(8.03±3.99)mmol/L)] in group B were lower than those in group A[(175.33±26.82)μmol/L,(10.15±4.31)mmol/L)](P<0.05).The fasting blood glucose, blood glucose 2 hours after meal and glycosylated hemoglobin[(7.15±1.85)mmol/L,(8.03±1.74)mmol/L,(6.38±1.16)%)] were lower than those in group A[(8.22±2.03)mmol/L,(10.67±2.16)mmol/L,(7.52±1.23)%)](P<0.05).The incidence of adverse reactions in group B(12.20%,5/41) was similar to that in group A(9.76%,4/41)(P>0.05).Conclusion The therapeutic effect of Jianpi Bushen Wenyang Formula in the elderly patients with diabetic nephropathy syndrome is significant, which can quickly relieve the clinical symptoms, improve the renal function index, reduce the blood sugar level, and there is no new adverse reaction compared with the simple western medicine treatment.It is worthy of clinical implementation.

关 键 词：健脾补肾温阳方 老年糖尿病肾病综合征 疗效 中医证候评分 SCr BUN 

分 类 号：R587.2[医药卫生—内分泌]