真武汤加减治疗痰瘀互结型2型糖尿病肾病患者的疗效及对血管内皮生长因子的影响  

Effect of Modified Zhenwu Decoction(真武汤)in Treatment of Type 2 Diabetic Nephropathy with Phlegm and Blood Stasis and Influence on VEGF

作　　者：张曦旭 张珊珊[2] 代玉 杨潇[1] 江红[1] 王永[1] ZHANG Xixu;ZHANG Shanshan;DAI Yu;YANG Xiao;JIANG Hong;WANG Yong(The Second Affiliated Hospital of Liaoning University of Traditional Chinese Medicine,Shenyang 110034,Liaoning,China;Liaoning Provincial Corps Hospital of Chinese People's Armed Police Fore,Shenyang 110034,Liaoning,China;Tieling Hospital of Traditional Chinese medicine,Tieling 112000,Liaoning,China)

机构地区：[1]辽宁中医药大学附属第二医院,辽宁沈阳110034 [2]武警辽宁省总队医院,辽宁沈阳110034 [3]铁岭市中医医院,辽宁铁岭112000

出　　处：《辽宁中医杂志》2021年第6期99-102,共4页Liaoning Journal of Traditional Chinese Medicine

摘　　要：目的探析真武汤联合盐酸二甲双胍治疗痰瘀互结型2型糖尿病肾病患者的临床疗效及对血管内皮生长因子的影响。方法将该院2019年2月—2020年2月收治的90例痰瘀互结型2型糖尿病肾病患者按照不同疗法纳入对照组(45例)与试验组(45例),对照组予以盐酸二甲双胍缓释片治疗,试验组予以真武汤联合盐酸二甲双胍缓释片治疗,对比两组患者的临床疗效、中医证候评分、血脂水平(总胆固醇、甘油三酯、高密度脂蛋白胆固醇、低密度脂蛋白胆固醇)、血糖水平(空腹血糖、餐后2 h血糖、糖化血红蛋白数)以及血管内皮生长因子水平。结果试验组的总有效率(91.11%,41/45)高于对照组(75.56%,34/35)(P<0.05);试验组治疗后的中医证候评分(12.7±2.4)分低于对照组(15.9±2.7)分(P<0.05);试验组治疗后的总胆固醇、甘油三酯、高密度脂蛋白胆固醇、低密度脂蛋白胆固醇水平[(4.22±0.60)mmol/L、(1.15±0.24)mmol/L、(1.68±0.32)mmol/L、(2.25±0.43)mmol/L]均优于对照组[(5.75±0.83)mmol/L、(2.68±0.32)mmol/L、(1.25±0.35)mmol/L、(3.88±0.96)mmol/L](P<0.05);试验组治疗后的空腹血糖、餐后2 h血糖、糖化血红蛋白水平[(7.11±1.85)mmol/L、(8.14±1.77)mmol/L、(6.40±1.15)%]均低于对照组[(8.24±2.02)mmol/L、(10.69±2.11)mmol/L、(7.51±1.20)%](P<0.05);试验组治疗后的血管内皮生长因子水平[(172.7±32.4)pg/mL]低于对照组[(265.9±72.7)pg/mL](P<0.05)。结论真武汤联合盐酸二甲双胍治疗痰瘀互结型2型糖尿病肾病患者的临床疗效满意,总有效率高,能够明显改善患者的临床症状,且有助于调节血脂、血糖以及血管内皮生长因子水平,适合在临床中推广并应用。Objective To explore the clinical effect of Zhenwu Decoction(真武汤) combined with metformin hydrochloride in the treatment of type 2 diabetic nephropathy of phlegm and blood stasis type and the effect on vascular endothelial growth factor.Methods Ninety cases of type 2 diabetic nephropathy with phlegm and blood stasis were included into the control group(45 cases) and the treatment group(45 cases).The control group was treated with metformin hydrochloride sustained-release tablets.The treatment group was treated with Zhenwu Decoction and metformin salt sustained-release tablets.The clinical efficacy,TCM syndrome score and blood pressure of the two groups were compared.Lipid levels(total cholesterol,triglyceride,high-density lipoprotein cholesterol,low-density lipoprotein cholesterol),blood glucose levels(fasting blood glucose,2 hours postprandial blood glucose,glycosylated hemoglobin) and vascular endothelial growth factor level were compared.Results The total effective rate(91.11%,41/45) in the treatment group was higher than that in the control group(75.56%,34/45)(P<0.05).The TCM syndrome score[(12.7±2.4)points] in the treatment group was lower than that in the control group[(15.9±2.7)points](P<0.05).The levels of total cholesterol,triglyceride,high-density lipoprotein cholesterol and low-density lipoprotein cholesterol in the treatment group[(4.22±0.60)mmol/L,(1.15±0.24)mmol/L,(1.68±0.32)mmol/L,(2.25±0.43)mmol/L] were better than those of the control group[(5.75±0.83)mmol/L,(2.68±0.32)mmol/L,(1.25±0.35)mmol/L,(3.88±0.96)mmol/L](P<0.05).The levels of fasting blood glucose,2 hours postprandial blood glucose and glycosylated hemoglobin in the treatment group[(7.11±1.85)mmol/L,(8.14±1.77)mmol/L,(6.40±1.15)%] were lower than those of the control group[(8.24±2.02)mmol/L,(10.69±2.11)mmol/L,(7.51±1.20)%](P<0.05).The level of vascular endothelial growth factor[(172.7±32.4)pg/mL] in the treatment group was lower than that in the control group[(265.9±72.7)pg/mL](P<0.05).Conclusion The clinical effec

关 键 词：真武汤 盐酸二甲双胍 痰瘀互结型 2型糖尿病肾病 临床疗效 血管内皮生长因子 

分 类 号：R692[医药卫生—泌尿科学]