日本乙型脑炎病毒E蛋白毒力相关氨基酸位点的研究进展  

Research progress on the virulence-related amino acid sites of Japanese encephalitis virus E protein

作　　者：晏仁潭 汤德元[1] 张森 韩超逸 杨志刚 罗柳 陈阊峥 YAN Ren-tan;TANG De-yuan;ZHANG Sen;HAN Chao-yi;YANG Zhi-gang;LUO Liu;CHEN Chang-zheng(College of Animal Science,Guizhou University,Guiyang 550025,China)

机构地区：[1]贵州大学动物科学学院,贵州贵阳550025

出　　处：《中国兽医科学》2021年第7期908-912,共5页Chinese Veterinary Science

基　　金：贵州大学国家自然科学基金前期项目(5781-8)。

摘　　要：日本乙型脑炎是由日本乙型脑炎病毒(JEV)引起的一种虫媒性、人兽共患急性流行性传染病。该病毒通过入侵人、猪、马和野生动物的脑神经引起病毒性脑炎,对人和动物造成严重的危害。E蛋白是JEV的毒力蛋白,E蛋白某些毒力氨基酸位点突变会改变JEV的致病性,这些位点通常被作为检测弱毒疫苗质量关键监测目标和判断野毒JEV变异毒力强弱的依据。本文对JEV E蛋白毒力相关氨基酸位点的研究进展进行综述,为研究JEV减毒分子机制和预防JEV变异提供理论基础。Japanese encephalitis is a kind of vector-borne,zoonotic acute infectious disease caused by Japanese encephalitis virus(JEV).The virus causes viral encephalitis by invading the brain nerves of humans,pigs,horses and wild animals,it is harmful to humans and animals.E protein is the virulence protein of JEV.Come virulence amino acid site mutations of E protein can change the pathogenicity of JEV.These sites are usually used as key targets for detecting the quality of attenuated vaccines and judging the virulence of wild virus JEV mutations.Basis This article reviews the research progress of the virulence-related amino acid sites of JEV E protein,and provides a theoretical basis for studying the molecular mechanism of JEV attenuation and preventing JEV mutation.

关 键 词：日本乙型脑炎病毒(JEV) E蛋白 E蛋白关键位点 氨基酸突变 毒力减弱 毒力增强 

分 类 号：S852.659.6[农业科学—基础兽医学]