干细胞及其仿生基质微环境在关节软骨再生修复中的作用综述  

Role of Stem Cells and Their Biomimetic Matrix Microenvironment in Regenerative Repair of Articular Cartilage:A Review

作　　者：曹洪芙 李珠廉 孙勇 樊渝江[1,2] 张兴栋[1,2] CAO Hong-fu;LI Zhu-lian;SUN Yong;FAN Yu-jiang;ZHANG Xing-dong(National Engineering Research Center for Biomedical Materials,Sichuan University,Chengdu 610064,China;College of Biomedical Engineering,Sichuan University,Chengdu 610064,China)

机构地区：[1]四川大学国家生物医学材料工程技术研究中心,成都610064 [2]四川大学生物医学工程学院,成都610064

出　　处：《四川大学学报（医学版）》2021年第4期548-554,共7页Journal of Sichuan University(Medical Sciences)

基　　金：国家重点研发计划重点专项(No.2018YFC1105900);国家自然科学基金面上项目(No.32071352);四川省重点研发计划重点专项(No.2019YFS0007)资助。

摘　　要：关节软骨由于无神经、无血管的特性,一旦损伤,其自我修复十分困难。干细胞技术的发展为关节软骨再生提供了新的希望。当前,不同来源的干细胞及多种应用方式在关节软骨修复中展现出不同程度的治疗效果。然而,干细胞对其所处的微环境均有极强的敏感性,这使得越来越多的研究者开始关注通过生物功能性支架构建的仿生微环境来调控干细胞,进而加速软骨再生。本文主要讨论了软骨修复的干细胞来源、其应用手段及其协同仿生细胞微环境在关节软骨修复方面的治疗效果、机制和应用不足。希望对协同干细胞的功能性软骨修复支架的设计和优化提供更加切实的临床化研究思路。It is difficult for the articular cartilage to self-heal any damage it may incur due to its lack of nerves and blood vessels.Development in stem cell technology provides new prospects for articular cartilage regeneration.Currently,stem cells from different sources and their diverse applications have demonstrated different degrees of therapeutic effect and potential in articular cartilage repair.However,stem cells are highly sensitive to their microenvironment.Therefore,more and more researchers are focusing their attention on regulating stem cells and thus accelerating cartilage regeneration through the biomimetic microenvironment constructed by biologically functional scaffolds.We reviewed in this paper the sources of the stem cells used for cartilage repair,the application method of these stem cells,as well as the therapeutic effect,mechanism and limitations in the application of stem cells synergizing with the biomimetic microenvironment in promoting articular cartilage repair and regeneration.We hoped to provide suggestions for practical clinical research in the design and improvement of biofunctional cartilage repair scaffolds that synergize with stem cells.

关 键 词：关节软骨修复 干细胞 生物功能性支架材料 仿生细胞微环境 

分 类 号：R687.4[医药卫生—骨科学]