2014-2020年西安市利福平耐药肺结核流行趋势分析  

Trend analysis of incidence for rifampicin-resistant tuberculosis in Xi’an from 2014 to 2020

作　　者：崔彩岩[1] 曾令城[1] 李于于[1] 高凡 王春娟[1] CUI Cai-yan;ZENG Ling-cheng;LI Yu-yu;GAO Fan;WANG Chun-juan(Xi’an Center for Disease Control and Prevention,Xi’an,Shaanxi 710054,China)

机构地区：[1]西安市疾病预防控制中心,陕西西安710054

出　　处：《现代预防医学》2021年第14期2659-2663,共5页Modern Preventive Medicine

基　　金：西安市科技局项目(J201903057)。

摘　　要：目的分析2014—2020年西安市利福平耐药肺结核(rifampicin-resistant tuberculosis,RR-TB)的发病情况及流行趋势,为制定防控策略和措施提供科学依据。方法收集西安市2014—2020年肺结核登记资料,采用Joinpoint回归模型评价西安市近年来利福平耐药肺结核报告发病率的时间变化趋势。结果2014—2020年西安市共报告RR-TB患者810例,RR-TB患者在新增肺结核病患者中比例呈逐年上升趋势,平均每年上升19.00%;RR-TB平均粗报告发病率为1.22/10万,标化报告发病率在0.53~2.07/10万之间,标化报告发病率在2014—2020年呈逐年上升趋势。男性平均报告标化发病率为1.57/10万,女性平均报告标化发病率为0.72/10万,2014—2020年均呈逐年上升趋势,平均每年上升分别为26.6%和16.1%,其中男性≥65岁组上升速度最快,平均每年上升82.5%,其次为男性55~64岁组(39.2%)和男性15~24岁组(30.3%);RR-TB患者中初治患者的比例为77.41%,呈逐年上升趋势,平均每年上升15.1%。结论2014—2020年西安市RR-TB报告发病率呈逐年上升趋势,应扩大耐药筛查范围,重点关注男性青年及老年人群,及早发现并治疗RR-TB患者,减少耐药结核杆菌的持续传播。Objective To analyze the incidence and epidemiological trends of rifampicin-resistant tuberculosis(RR-TB) in Xi’an from 2014 to 2020, so as to provide scientific basis for prevention and control strategies. Methods The data of pulmonary tuberculosis registration in Xi’an from 2014 to 2020 were collected, and Joinpoint regression model was used to evaluate the temporal trends of the reported incidence of Rifampicin-resistant tuberculosis in Xi ’an in recent years. Results A total of 810 cases of RR-TB were reported in Xi’an from 2014 to 2020, and the proportion of RR-TB patients among new pulmonary TB patients showed a yearly increasing trend, with an average annual increase of 19.00%. The average crude reported incidence rate of RR-TB was 1.22/100 000, and the standardized reported incidence rate ranged from 0.53/100 000 to 2.07/100 000, showing an increasing trend year by year from 2014-2020. The average reported standardized incidence rate for males was 1.57/100 000 and for females was 0.72/100 000, both of which showing an increasing trend from 2014 to2020, with an average annual increase of 26.6% and 16.1%, respectively. Among them, the 65+years old group of men had the highest increase rate, with an average annual increase of 82.5%, followed by the 55-64 years old group of men(39.2%)and the 15-24 years old group of men(30.3%). The proportion of RR-TB patients with a treatment classification of primary care was 77.41%, and the trend was increasing year by year, with an average annual increase of 15.1%. Conclusion The reported incidence of RR-TB in Xi’an from 2014 to 2020 showed an increasing trend year by year, and the scope of drugresistant screening should be expanded, focusing on the male youth and elderly population to detect and treat RR-TB patients early and reduce the continuous transmission of drug-resistant Mycobacterium tuberculosis.

关 键 词：RR-TB 发病率 流行趋势 西安市 

分 类 号：R521[医药卫生—内科学] R195.4[医药卫生—临床医学]