Notch信号影响内耳毛细胞再生的研究进展  

Advances in the effects of Notch signaling on inner ear hair cell regeneration

作　　者：王洋洋 郑怡 刘晶[2] 邢津骁 汤继芹 WANG Yangyang;ZHENG Yi;LIU Jing;XING Jinxiao;TANG Jiqin(School of Rehabilitation Medicine,Weifang Medical University,Weifang 261042,China;School of Rehabilitation Medicine,Shandong University of Traditional Chinese Medicine,Jinan 250355,China;School of Continuing Education,Shandong University of Traditional Chinese Medicine,Jinan 250355,China)

机构地区：[1]潍坊医学院康复医学院,潍坊261053 [2]山东中医药大学康复医学院,济南250355 [3]山东中医药大学继续教育学院,济南250355

出　　处：《中国眼耳鼻喉科杂志》2021年第4期309-311,315,共4页Chinese Journal of Ophthalmology and Otorhinolaryngology

基　　金：山东省医药卫生科技发展计划项目(2018WS205)。

摘　　要：感音神经性耳聋已经成为全球性难以解决的疾病之一,它主要是由传递耳蜗听觉信号的感觉毛细胞死亡引起。但是哺乳动物的耳蜗毛细胞缺乏再生能力。了解毛细胞发育的相关信号通路可以为再生策略提供信息,为治疗听力损伤提供新方法。典型的Notch通路对哺乳动物的耳蜗发育至关重要,它可调节耳蜗毛细胞的增殖、分化和再生。γ-分泌酶抑制剂、Math1、microRNA对Notch信号均有一定影响。本文就Notch调节通路负向调控感觉毛细胞的再生以及上述三者与Notch的关系展开论述,为治疗感音神经性耳聋提供依据。Hearing loss has become one of the most difficult diseases in the world. It is mainly caused by the death of sensory hair cells that transmit cochlear auditory signals. However, the mammalian cochlear hair cells lacks the ability to regenerate. It will provide information for regeneration strategies and develop new ways to treat hearing impairment after understanding the signaling pathways involved in hair cell development. The typical Notch pathway is critical for mammalian cochlear development to regulate hair cell proliferation, differentiation, and regeneration. γ-secretase inhibitors, Math1, and microRNA all have certain effects on Notch signaling. This article discusses the negative regulation of sensory hair cell regeneration and their relationship. It will provide an evidence for the treatment of sensorineural deafness.

关 键 词：NOTCH信号 感音神经性耳聋 毛细胞再生 Γ-分泌酶抑制剂 MATH1 

分 类 号：R764.43[医药卫生—耳鼻咽喉科]