止鼾安神汤联合持续气道正压通气治疗阻塞性睡眠呼吸暂停低通气综合征伴失眠患者的临床疗效分析  

Clinical Efficacy of Zhihan Anshen Decoction Combined with CPAP on the Treatment of Insomnia Patients with Obstructive Sleep Apnea Hypopnea Syndrome

作　　者：付桂玲[1] 刘颖 FU Guiling;LIU Ying(1 National Physician Hall,Beijing Changping Hospital of Integrated Traditional Chinese and Western Medicine,Beijing 102208,China;Department of General Surgerry,Beijing Miyun District Hospital of Traditional Chinese Medicine,Beijing 101500,China)

机构地区：[1]北京市昌平区中西医结合医院国医馆,北京102208 [2]北京市密云区中医医院普外科,北京101500

出　　处：《世界睡眠医学杂志》2021年第5期788-791,共4页World Journal of Sleep Medicine

摘　　要：目的:分析止鼾安神汤联合持续气道正压通气(CPAP)治疗阻塞性睡眠呼吸暂停低通气综合征(OSAHS)伴失眠患者的临床疗效。方法:选取2016年1月至2019年12月北京市昌平区中西医结合医院收治的OSAHS伴失眠患者72例作为研究对象,按照随机数字表法随机分为对照组和观察组,每组36例。对照组予以常规CPAP干预治疗,观察组在对照组的基础上联合应用止鼾安神汤。观察2组治疗前后多导睡眠监测(PSG)、爱泼沃斯嗜睡量表(ESS)、匹兹堡睡眠质量指数量表(PSQI)和失眠严重程度指数量表(ISI),评定2组患者失眠症状的改善情况。结果:观察组的总有效率为91.7%,对照组的总有效率为72.2%,2组总有效率比较差异有统计学意义(P<0.05),观察组总有效率显著高于对照组。2组患者治疗后AHI、最低SaO_(2)水平均优于治疗前(P<0.05),且观察组的AHI低于对照组,最低SaO_(2)水平高于对照组(P<0.05)。2组患者治疗后ESS、PSQI、ISI评分均较治疗前下降(P<0.05),且观察组治疗后ESS、PSQI、ISI评分与对照组比较,差异有统计学意义(P<0.05)。结论:止鼾安神汤联合CAPA治疗OSAHS伴失眠患者能显著改善其睡眠质量和打鼾情况,值得临床进一步推广使用。Objective:To analyze the clinical efficacy of Zhihan Anshen Decoction in the treatment of insomnia patients with obstructive sleep apnea hypopnea syndrome(OSAHS).Methods:From January 2016 to December 2019,72 cases of OSAHS insomnia patients were randomly divided into control group and observation group,36 cases each.The control group was given continuous positive airway pressure(CPAP)intervention,and the observation group was given Zhihan Anshen Decoction on the basis.After treatment,polysomnography(PSG),Epworth Sleepiness Scale(ESS),Pittsburgh sleep quality index(PSQI)and insomnia severity index(ISI)were used to observe the improvement of insomnia symptoms.Results:After treatment,the total effective rate of the observation group was 91.7%,and that of the control group was 72.2%.The total effective rate of the observation group was significantly higher than that of the control group(P<0.05).The improvement of PSG indexes in the two groups after treatment was better than those before treatment,and the observation group significantly better(P<0.05).The ESS,PSQI and ISI scores of the two groups after treatment were decreased(P<0.05),and there were significant differences in the observation group compared with the control group after treatment(P<0.05).Conclusion:Zhihan Anshen Decoction with CPAP in the treatment of OSAHS patients with insomnia can significantly improve the sleep quality and snoring,which is worthy of further clinical application.

关 键 词：阻塞性睡眠呼吸暂停低通气综合征 失眠 止鼾安神汤 

分 类 号：R243[医药卫生—中医临床基础] R454.4[医药卫生—中医学]