度洛西汀治疗骨关节炎疼痛研究进展  

Advancement of duloxetine in treatment of osteoarthritis pain

作　　者：鲍哲明 单青 李晨[3] 陈孟莉[1] Bao Zheming;Shan Qing;Li Chen;Chen Mengli(Pharmacy Department,Chinese PLA General Hospital,Beijing 100089,China;Orthopedics department,960th Hospital of PLA Joint Service Support Force,Jinan 250031,China;Translational Medicine Laboratory,Chinese PLA General Hospital,Beijing 100089,China)

机构地区：[1]中国人民解放军总医院医疗保障中心药剂科,北京100089 [2]中国人民解放军联勤保障部队第960医院骨科,济南250031 [3]中国人民解放军总医院医疗保障中心创新医学部转化医学试验室,北京100089

出　　处：《中华关节外科杂志（电子版）》2021年第3期318-323,共6页Chinese Journal of Joint Surgery(Electronic Edition)

基　　金：军队课题基金(16BJZ20)。

摘　　要：目前针对骨关节炎的药物治疗主要目的是缓解疼痛,提高关节功能。骨关节炎慢性持续性疼痛往往伴随有神经性疼痛的特点以及中枢敏感化现象。目前认为度洛西汀作为5-羟色胺和去甲肾上腺素再摄取抑制剂,能通过下行疼痛调节系统治疗神经性疼痛,同时一些研究中也发现了度洛西汀在治疗疼痛中存在的抗炎作用。在治疗骨关节炎疼痛的临床实验和研究中,度洛西汀能够有效缓解骨关节炎疼痛,并且具有良好的安全性和耐受性。在此,本文就度洛西汀治疗骨关节炎疼痛相关研究报道作一综述。Drug treatments for osteoarthritis are primarily targeted at relieving pain,improving joint function.Chronic persistent pain in osteoarthritis is often accompanied by neuropathic pain and central sensitization.Duloxetine,a serotonin and norepinephrine reuptake inhibitor,is used in the treatment of neuropathic pain through the descending pain modulatorysystem,and some studies have also found the anti-inflammatory activity of duloxetine in the treatment of pain.Duloxetine has been shown to be effective in relieving osteoarthritis pain in reported clinical trials and studies with good safety and tolerability profiles.This review mainly aimed at the related reports of duloxetine in the treatment of osteoarthritis pain.

关 键 词：盐酸度洛西汀 骨关节炎 疼痛 

分 类 号：R68[医药卫生—骨科学]