S-腺苷蛋氨酸联合地塞米松对妊娠肝内胆汁淤积症患者妊娠结局、胆汁酸及肝酶指标的影响  

Effects of S-adenosylmethionine Combined with Dexamethasone on Pregnancy Outcome,Bile Acid and Liver Enzyme Indexes in Patients with Intrahepatic Cholestasis of Pregnancy

作　　者：黄裕凤 黄彩云[1] 吴晓冰 HUANG Yu-Feng;HUANG Cai-Yun;WU Xiao-Bing(Department of Obstetrics and Gynecology,People's Hospital of Gaoming District,Foshan 528599,China)

机构地区：[1]佛山市高明区人民医院妇产科,广东佛山528599

出　　处：《中国药物经济学》2021年第7期80-83,共4页China Journal of Pharmaceutical Economics

摘　　要：目的探讨S-腺苷蛋氨酸联合地塞米松对妊娠肝内胆汁淤积症患者妊娠结局、胆汁酸及肝酶指标的影响。方法选取2016年3月至2020年3月在佛山市高明区人民医院接受治疗的妊娠肝内胆汁淤积症患者90例作为研究对象,随机分为对照组与观察组,每组45例。对照组给予S-腺苷蛋氨酸,观察组在对照组基础上加用盐酸地塞米松注射液治疗。比较两组患者临床疗效、妊娠结局、胆汁酸、胆红素及肝酶指标水平。结果观察组治疗有效率为95.56%,高于对照组的82.23%(P<0.05)。观察组不良妊娠结局发生率为6.66%,低于对照组的22.22%(P<0.05)。治疗后两组患者总胆汁酸及总胆红素水平明显下降,但观察组下降幅度更大,差异有统计学意义(P<0.05)。治疗后两组患者丙氨酸转氨酶、天冬氨酸转氨酶水平明显下降,但观察组下降幅度更大,差异有统计学意义(P<0.05)。结论S-腺苷蛋氨酸联合地塞米松较单独使用S-腺苷蛋氨酸可有效提高妊娠肝内胆汁淤积症患者临床疗效,减少不良妊娠结局发生,改善胆汁酸及肝酶指标。Objective To investigate the effect of S-adenosylmethionine combined with dexamethasone on pregnancy outcome,bile acid and liver enzymes in patients with intrahepatic cholestasis of pregnancy.Methods A total of 90 patients with intrahepatic cholestasis of pregnancy who were admitted to People’s Hospital of Gaoming District from March 2016 to March 2020 were selected as the research objects and were randomly assigned into a control group and an observation group,with 45 cases in each group.The control group was given S-adenosylmethionine for injection,and the observation group was given dexamethasone hydrochloride injection plus S-adenosylmethionine for injection.The clinical efficacy,pregnancy outcome,bile acid,liver enzyme and bilirubin levels of the 2 groups were compared.Results The total effective rate in the observation group was 95.56%,which was higher than 82.23% in the control group(P<0.05).The incidence of adverse pregnancy outcomes in the observation group was 6.66%,which was lower than 22.22% in the control group(P<0.05).After treatment,the total bile acid and total bilirubin levels of the 2 groups of patients decreased significantly,but the decrease in the observation group was even greater,the difference was statistically significant(P<0.05).After treatment,the levels of alanine aminotransferase and aspartate aminotransferase of the 2 groups of patients decreased significantly,but the decline in the observation group was even greater,the difference was statistically significant(P<0.05).Conclusion S-adenosylmethionine combined with dexamethasone can effectively improve the clinical efficacy of patients with intrahepatic cholestasis of pregnancy,improve the pregnancy outcome,and improve bile acid and liver enzyme indexes.

关 键 词：S-腺苷蛋氨酸 地塞米松 妊娠肝内胆汁淤积症 肝功能 

分 类 号：R714.2[医药卫生—妇产科学] R984[医药卫生—临床医学]