白细胞介素21在心血管系统疾病中的研究进展  

Research progress of interleukin-21 in cardiovascular diseases

作　　者：陈静[1] 梅仁彪[1] 王瑜[1] CHEN Jing;MEI Ren-Biao;WANG Yu(Department of Basic Medical Sciences,Medical College,Anhui University of Science&Technology School of Medicine,Huainan 232001,China)

机构地区：[1]安徽理工大学医学院,安徽淮南232001

出　　处：《中国病理生理杂志》2021年第7期1317-1323,共7页Chinese Journal of Pathophysiology

基　　金：安徽高校省级自然科学重点研究项目(No.KJ2017A098,No.KJ2012A082);安徽理工大学博士科研基金(No.11046);安徽理工大学中青年学术骨干培养工程(No.10167)。

摘　　要：白细胞介素21(interleukin-21,IL-21)是一种Ⅰ型细胞因子,属于γ链(γ-chain,γc)复合受体型细胞因子家族成员[1],主要由滤泡辅助性T细胞(T follicu-lar helper cells,Tfh cells)、辅助性T细胞17(T helper 17 cells,Th17 cells)和自然杀伤(natural killer,NK)细胞产生[2],对天然免疫反应和获得性免疫反应均有多效性作用[3]。目前心血管疾病的发病率逐年上升[4],临床确认慢性炎症是心血管疾病的关键因素[5],但其具体机制尚不完全清楚.Interleukin-21(IL-21)is a type I cytokine,which belongs to theγ-chain cytokine family,specifi-cally produced by T helper 17(Th17)cells,T follicular helper(Tfh)cells and natural killer(NK)cells.In recent years,more and more studies have demonstrated that IL-21 has an interesting relationship with various cardiovascular diseases,including hypertension,pulmonary arterial hypertension and so on,and IL-21 signaling may play an important role in car-diovascular diseases.Here,we summarize the related research on the source,function and regulation of IL-21 and the roles of IL-21 signaling in cardiovascular diseases.

关 键 词：白细胞介素21 心血管疾病 炎症 

分 类 号：R541[医药卫生—心血管疾病] R363[医药卫生—内科学]