基于基因调控探讨胃癌前病变中医药治疗进展  

Review on the progress of treating gastric precancerous lesions with traditional Chinese medicine based on regulatory genes

作　　者：梁国英[1] 丁艺 奚玉杰 刘金凤[2] 蔡宏波[1] LIANG Guo-ying;DING Yi;XI Yu-jie;LIU Jin-feng;CAI Hong-bo(The First Affiliated Hospital of Heilongjiang University of Traditional Chinese Medicine,Harbin 150040,China;Heilongjiang University of Traditional Chinese Medicine,Harbin 150040,China)

机构地区：[1]黑龙江中医药大学附属第一医院,哈尔滨150040 [2]黑龙江中医药大学,哈尔滨150040

出　　处：《海南医学院学报》2021年第15期1197-1200,共4页Journal of Hainan Medical University

基　　金：博士后研究人员落户黑龙江科研启动资助金(LBH-Q17169);全国中医临床特色技术传承骨干人才培训项目(国中医药人教函[2019]36号);第六批全国老中医药专家学术经验继承工作项目(No.:国中医药人教发[2017]29号)。

摘　　要：近年来胃癌前病变(precancerous lesions of gastric cancer,PLGC)的发病率逐渐升高,且具有迁延难愈,易反复发作等特点。中医药强调未病先防,针对其病因病机辨证论治,在逆转PLGC方面有显著优势,中医药对PLGC相关肿瘤基因的调控更是成为研究热点。本文总结了PLGC相关原癌基因、抑癌基因、细胞凋亡相关基因,从基因表达的角度探讨中医药治疗PLGC的作用机制,为临床治疗PLGC提供新思路及方法。In recent years,the incidence of precancerous lesions of gastric cancer(PLGC)has gradually increased,and it is difficult to be cured and easy to recur. Traditional Chinese Medicine(TCM)emphasizes the prevention before the disease. The regulation of PLGC related tumor genes by Chinese medicine has become a research hotspot. This paper summarized PLGC related proto-oncogenes,tumor suppressor genes and apoptosis related genes,and discussed the mechanism of Chinese Medicine Therapy PLGC from the perspective of gene expression,providing new ideas and methods for clinical treatment of PLGC.

关 键 词：胃癌前病变 中医药 基因 作用机制 

分 类 号：R273[医药卫生—中西医结合]