深圳地区10~40周岁健康人群血清抗A(B)IgG抗体效价参考区间的建立与应用分析  

Establishment and Application Analysis of Serum Anti-A(B)IgG Antibody Titer Reference Interval of Healthy People Aged 10~40 in Shenzhen Area

作　　者：魏俊杰 WEI Jun-jie(Department of Transfusion Medicine,Shenzhen Hospital of Southern Medical University,,Guangdong Shenzhen 518000,China)

机构地区：[1]南方医科大学深圳医院输血科,广东深圳518000

出　　处：《现代检验医学杂志》2021年第4期136-138,共3页Journal of Modern Laboratory Medicine

基　　金：深圳市宝安区科技创新局项目(项目编号:2020JD451);深圳市科技创新委员会项目(项目编号:JCYJ20190814110401673)。

摘　　要：目的建立深圳地区10~40周岁健康人群血清IgG抗A(B)抗体效价参考区间。方法选取深圳地区年龄为10~40周岁南方医科大学深圳医院健康未孕体检者共1500例,按性别分成男女2组,每组再按照年龄分成3个亚组,检测血清IgG抗A(B)抗体效价。结果深圳地区10~40周岁健康人群血清IgG抗A(B)抗体效价参考区间范围为1:8~1:64。IgG抗A抗体效价以及IgG抗B抗体效价,在不同性别中分布差异无统计学意义(χ^(2)=0.492,1.011,均P>0.05)。IgG抗A抗体效价在3个年龄亚组中分布差异无统计学意义(χ^(2)=5.464,P>0.05),但IgG抗B抗体效价在3个年龄亚组中分布差异有统计学意义(χ^(2)=10.083,P<0.05)。结论深圳地区10~40岁健康人群血清IgG抗A(B)抗体效价区间范围为1:8~1:64,可为预测新生儿溶血病(HDN)的发病预警提供基础数据和科学依据。Objective To establish a reference interval for serum IgG anti-A(B)antibody titer of healthy people aged 10~40 in Shenzhen.Methods A total of 1500 healthy unpregnant healthy persons aged 10~40 in Shenzhen Hospital of Southern Medical University for physical examination were recruited in Shenzhen.The subjectswere divided into 2 groups according to gender,and eachgroup was divided into 3 subgroups according to age.The antibody titer of IgG anti-A(B)in serum was tested and analyzed in each group.Results The reference range of serum IgG anti-A(B)antibody titer of healthy people aged 10~40 in Shenzhen was 1:8~1:64.There were no significant differences in the difference in the distribution of IgG anti-A antibody titer and IgG anti-B antibody titer between different genders(χ^(2)=0.492,1.011,all P>0.05).The IgG anti-A antibody titer in the three age subgroups was not statistically different(χ^(2)=5.464,P>0.05),but the IgG anti-B antibody titer was statistically significant differences in the three age subgroups(χ^(2)=10.083,P<0.05).Conclusion The titer range of serum IgG anti-A(B)antibody in healthy people aged 10~40 in Shenzhen was 1:8~1:64,which can provide basic data supporting and scientific basis for predicting the early warning of Hemolytic Disease of the Newborn(HDN).

关 键 词：健康人群 血清IgG抗A(B)效价 效价区间 

分 类 号：R457.12[医药卫生—治疗学]