张洪春教授治疗慢阻肺稳定期用药规律探析  

Professor Zhang Hongchun's medication rule in treating patients with stable chronic obstructive pulmonary diseases

作　　者：刘迪[1,2] 张巍[3] 张洪春 LIU Di;ZHANG Wei;ZHANG Hong-chun(Beijing University of Chinese Medicine,Beijing 100029,China;Department of Traditional Chinese Medicine for Pulmonary Diseases,Center of Respiratory Medicine,China-Japan Friendship Hospital,Beijing 100029,China;Zuojiazhuang Community Health Service Center,Beijing 100029,China)

机构地区：[1]北京中医药大学,北京100029 [2]中日友好医院呼吸中心,中医肺病科,北京100029 [3]左家庄社区卫生服务中心,北京100029

出　　处：《海南医学院学报》2021年第14期1104-1108,1115,共6页Journal of Hainan Medical University

基　　金：中医药传承与创新“百千万”人才工程(岐黄工程)(2019-QTL-003)。

摘　　要：目的:基于中医传承辅助平台分析张洪春教授治疗慢性阻塞性肺疾病稳定期患者的用药规律。方法:收集整理张洪春教授治疗慢阻肺稳定期患者的处方,对其进行频数统计、关联规则、复杂系统熵聚类等分析。结果:共筛选出111诊次处方,包含中药100味,药性以温、寒、平为主,药味以甘、苦、辛为主,归经多归属于肺、脾、肝、肾经,提取药物核心组合34个,置信度为1的关联规则38条,得到新处方3个,核心处方为:当归15 g、太子参30 g、山茱萸15 g、五味子15 g、款冬花15 g、紫菀15 g、茯苓15 g、紫苏子15 g、紫苏叶15g、麻黄10 g、甘草3 g。结论:张洪春教授以补益肺脾肾为基本治法,兼以止咳化痰平喘、行气活血散瘀来治疗慢阻肺稳定期患者。Objective:To analyze the medication rule of Professor Zhang Hongchun in treating patients with chronic ob⁃structive pulmonary diseases(COPD)during stable period based on the Traditional Chinese Medicine Inheritance Support Sys⁃tem.Methods:The prescriptions of Professor Zhang Hongchun in treating stable COPD patients were collected and analyzed for their frequency statistics,association rules and complex system entropy clustering.Results:A total of 111 prescriptions were screened out,including 100 kinds of traditional Chinese medicine,which were mainly warm,cold and mild in nature,and sweet,bitter and pungent in flavor.The meridians were mostly attributed to the lung,spleen,liver and kidney.A total of 34 core combi⁃nations of drugs were extracted,and 38 association rules with confidence level of one were obtained.Moreover,3 new prescrip⁃tions were obtained.The core prescriptions included:Angelicae sinensis radix(15 g),Radix pseudostellariae(30 g),Cornus of⁃ficinalis Sieb.et Zucc.(15 g),Schisandrae chinensis fructus(15 g),Farfarae flos(15 g),Asteris radix et rhizoma(15 g),Po⁃ria cocos(Schw.)Wolf(15 g),Perillae fructus(15 g),Perilla frutescens(15 g),Ephedra herba(10 g),and licorice(3 g).Conclusion:Professor Zhang Hongchun's treatment methods of stable COPD patients are to invigorate the lung,spleen and kid⁃ney,stop cough,eliminate phlegm and asthma,promote Qi,activate blood circulation and dissipate blood stasis.

关 键 词：慢性阻塞性肺疾病 中医传承辅助平台 张洪春 用药规律 

分 类 号：R259[医药卫生—中西医结合] R249[医药卫生—中医内科学]