BCAP在变应性鼻炎患者外周血中的差异性表达  

Differential expression of BCAP gene in patients with allergic rhinitis

作　　者：杨心怡 孙海勇 冀德君[4] 关兵 YANG Xinyi;SUN Haiyong;JI Dejun;GUAN Bing(Weifang People’s Hospital,Weifang,Shandong,261000,China)

机构地区：[1]山东省潍坊市人民医院,261000 [2]扬州大学临床医学院 [3]江苏省苏北人民医院,扬州 [4]扬州大学动物科学与技术学院

出　　处：《中国中西医结合耳鼻咽喉科杂志》2021年第3期184-187,共4页Chinese Journal of Otorhinolaryngology in Integrative Medicine

基　　金：江苏省卫生和计划生育委员会面上课题(NO:H2017058),江苏省自然科学基金(BK20181221),江苏省自然科学基金(BK20201220)。

摘　　要：目的进一步验证BCAP通过激活PI3K引起炎性反应症状,高水平BCAP可能会促进变应性鼻炎的发生。方法采集21例变应性鼻炎患者和6名健康志愿者的外周血样本,对血浆中BCAP水平进行ELISA测定。结果变应性鼻炎患者血浆中BCAP含量显著高于健康对照,与先前转录组分析结果一致。结论变应性鼻炎患者中BCAP基因表达显著增强,在变应性鼻炎的发病过程中起着重要作用。Objective To further verify that BCAP causes inflammatory response symptoms by activating PI3K,and that high levels of BCAP may promote allergic rhinitis.Methods Peripheral blood samples were collected from 21 patients with allergic rhinitis and 6 healthy volunteers,and the plasma BCAP level was measured by ELISA.Results The content of BCAP in plasma of patients with allergic rhinitis was significantly higher than that of healthy controls,which was consistent with the results of previous transcriptome analysis.Conclusion BCAP gene expression is significantly enhanced in allergic rhinitis,which plays an important role in the pathogenesis of allergic rhinitis.

关 键 词：变应性鼻炎 B细胞衔接蛋白 酶联免疫吸附试验 差异性表达 

分 类 号：R765.21[医药卫生—耳鼻咽喉科]