Natural and unnatural anthraquinones isolated from the ethanol extract of the roots of Knoxia valerianoides  

作　　者：Feng Zhao Sujuan Wang Sheng Lin Chenggen Zhu Zhenggang Yue Yang Yu Bo Liu Xiuli Wu Yongchun Yang Yan Li Jiangong Shi 

机构地区：[1]State Key Laboratory of Bioactive Substance and Function of Natural Medicines,Institute of Materia Medica,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing 100050,China

出　　处：《Acta Pharmaceutica Sinica B》2012年第3期260-266,共7页药学学报（英文版）

基　　金：Financial support from the National Natural Sciences Foundation of China(NNSFC,grant Nos.30825044 and 20932007);the National Science and Technology Project of China(No.2009ZX09311-004)is acknowledged.

摘　　要：Eight new 9,10-anthraquinones(1-8)including three acetonide derivatives of 3-hydroxy-2-hydroxymethyl-9,10-anthraquinones(68)were isolated from an ethanol extract of the roots of Knoxia valeriamoides.On the basis of chemical transformation reactions of the co-occurring 14 and 15 combined with HPLC-DAD-ESI-MS analysis of the extracts,the previously and newly isolated 2-methoxymethy-and 2-ethoxymethyl-9,10-anthraquinones(4,5,and 9-13),as well as the 3-hydroxy-2-hydroxymethyl-9,10-anthraquinone acetonide derivatives(68),were shown to be solvolytic artifacts.In the in vitro assays,compound 4 was active to protect hepatocyte(WB-F344)damage.

关 键 词：Knoxia valerianoides RUBIACEAE ANTHRAQUINONE Solvolytic artifacts HPLC-DAD-ESI-MS analysis Hepatocyte(WB-F344)damage protection 

分 类 号：O62[理学—有机化学]