Fundamental aspects of solid dispersion technology for poorly soluble drugs  

作　　者：Yanbin Huang Wei-Guo Dai 

机构地区：[1]Key Laboratory of Advanced Materials(MOE),Department of Chemical Engineering,Tsinghua University,Beijing 100084,China [2]Janssen Research and Development,Johnson&Johnson Company,Randor 19087,PA,USA

出　　处：《Acta Pharmaceutica Sinica B》2014年第1期18-25,共8页药学学报（英文版）

基　　金：This work was supported by the National Natural Science Foundation of China(Grant No.50873056 to Y.H.).

摘　　要：The solid dispersion has become an established solubilization technology for poorly water soluble drugs.Since a solid dispersion is basically a drug-polymer two-component system,the drug-polymer interaction is the determining factor in its design and performance.In this review,we summarize our current understanding of solid dispersions both in the solid state and in dissolution,emphasizing the fundamental aspects of this important technology.

关 键 词：Solid dispersion Poorly soluble drug Phase separation Drug-polymer interaction 

分 类 号：TG1[金属学及工艺—金属学]