Evaluation of percutaneous permeation of repellent DEET and sunscreen oxybenzone from emulsion-based formulations in artificial membrane and human skin  

作　　者：Tao Wang Donald Miller Frank Burczynski Xiaochen Gu 

机构地区：[1]Faculty of Pharmacy,University of Manitoba,Winnipeg,Manitoba R3E 0T5,Canada [2]Department of Pharmacology and Therapeutics,University of Manitoba,Winnipeg,Manitoba R3E 0T5,Canada

出　　处：《Acta Pharmaceutica Sinica B》2014年第1期43-51,共9页药学学报（英文版）

基　　金：support from Canada Foundation for Innovation(CFI);Manitoba Institute of Child Health(MICH);graduate studentship from MHRC(TW).

摘　　要：Insect repellent DEET and sunscreen ingredient oxybenzone play an essential role in minimizing vector-borne diseases and skin cancers.The purpose of this study was to investigate the effects of emulsion type,addition of thickening agent and droplet size in three emulsion-based lotions on percutaneous permeation of DEET and oxybenzone using in vitro diffusion experiments,in order to minimize overall systemic permeation of the substances.Formulation C(water-in-oil emulsion)significantly increased overall permeation of DEET through human skin(56%)compared to Formulation A(oil-in-water emulsion).Formulation B(oil-in-water emulsion with thickening agent xanthan gum)significantly decreased the size of oil droplet containing DEET(16%),but no effect on oil droplets containing oxybenzone.Adding xanthan gum also increased overall permeation of DEET and oxybenzone(21%and 150%)when compared to Formulation A;presence of both ingredients in Formulation B further increased their permeation(36%and 23%)in comparison to its single counterparts.Overall permeation of oxybenzone through LDPE was significantly higher by 26%-628%than that through human skin;overall permeation of DEET through human skin was significantly higher by 64%-338%than that through LDPE.

关 键 词：Diffusion Human skin Artificial membrane Permeability Concurrent use Insect repellent SUNSCREEN 

分 类 号：TQ4[化学工程]