合成生物学在推动肿瘤细菌疗法临床药物开发中的应用  

Application of Synthetic Biology in Promoting Preclinical and Clinical Advances of Bacterial Anti-Cancer Therapy

作　　者：刘陈立[1,2] 董宇轩 郭旋 LIU Chenli;DONG Yuxuan;GUO Xuan(CAS Key Laboratory of Quantitative Engineering Biology,Shenzhen Institute of Synthetic Biology,Shenzhen Institute of Advanced Technology,Chinese Academy of Sciences,Shenzhen 518055,China;University of Chinese Academy of Sciences,Beijing 100049,China)

机构地区：[1]中国科学院深圳先进技术研究院深圳合成生物学创新研究院中国科学院定量工程生物学重点实验室,深圳518055 [2]中国科学院大学,北京100049

出　　处：《集成技术》2021年第4期78-92,共15页Journal of Integration Technology

基　　金：国家重点研发计划项目(2018YFA0902701);中国科学院战略重点研究计划项目(XDB29050501,XDPB18);国家自然科学基金项目(32025022,3201101136);深圳市科技创新委员会项目(KQTD2015033117210153,JCYJ20170818164139781)。

摘　　要：细菌疗法是肿瘤治疗领域的重要发展方向之一,合成生物学的日益发展为肿瘤细菌疗法提供更多样化、更有效安全的治疗策略。该文概述了细菌治疗肿瘤领域的临床优秀范例,详细介绍了目前的研究进展及面临的瓶颈问题,并围绕肿瘤细菌疗法深入探讨了合成生物学在推动活菌药物临床开发中的应用。此外,针对临床活菌药物的有效性和生物安全性问题,展望了合成生物学在临床药物开发中的重要作用和未来发展趋势。Bacteriotherapy is one of the important direction in the field of cancer therapy.The increasing development of synthetic biology provides more diversified,more effective and safer therapeutic strategies for bacterial anti-cancer therapy.In this review,the excellent clinical examples in the field of bacterial anti-cancer therapy are summarized,the current research progress and bottleneck problems are introduced in detail.The application of synthetic biology in promoting the clinical development of live bacterial therapeutics is also discussed.Moreover,the important role and the future development trend of synthetic biology are prospected in view of the effectiveness and biosafety of clinical live bacterial therapeutics.

关 键 词：合成生物学 肿瘤细菌疗法 活菌治疗药剂 临床测试 

分 类 号：Q939.99[生物学—微生物学]