轻度认知功能障碍计算机辅助认知训练与Lp⁃PLA2和ApoEε4基因相关分析  

Correlation analysis between computer⁃assisted cognitive training and Lp⁃PLA2 and apoEε4 gene in pa⁃tients with mild cognitive impairment

作　　者：王理鑫 胡春雨 陈淅泠[1] WANG Lixin;HU Chunyu;CHEN Xiling(Department of Geriatrics,the Second Affiliated Hospital,Zhengzhou University,Zhengzhou 450014,China)

机构地区：[1]郑州大学第二附属医院老年医学科,郑州450014

出　　处：《实用医学杂志》2021年第14期1827-1831,共5页The Journal of Practical Medicine

基　　金：河南省高等学校重点科研项目计划(编号:19A320048)。

摘　　要：目的探讨计算机辅助认知训练(CCT)治疗轻度认知功能障碍疗效与血清Lp⁃PLA2和ApoEε4基因携带状态的相关性以及Lp⁃PLA2和ApoEε4基因相关作用机制。方法诊断为轻度认知功能障碍患者中随机选取55例为观察组,35例为对照组,干预措施为3个月的CCT,每周3次,每次20 min,训练前后进行神经心理学量表测评,检测血清Lp⁃PLA2水平和ApoEε4携带状态并评估其相关性。结果(1)观察组认知量表测评水平显著高于对照组(MMSE:t=2.250,P=0.027;MoCA:t=2.168,P=0.033);(2)观察组认知变化水平与Lp⁃PLA2(ΔMMSE:r=-0.276,P=0.041;ΔMoCA:r=-0.328,P=0.014)呈显著负相关;(3)ApoEε4携带者认知变化水平显著高于非携带者(ΔMMSE:t=-2.061,P=0.044;ΔMoCA:t=-2.406,P=0.020);(4)ApoEε4携带与否的Lp⁃PLA2水平差异有统计学意义(t=2.411,P=0.019)。结论应用CCT治疗轻度认知功能障碍患者认知功能有效,其疗效与ApoEε4基因携带状态和Lp⁃PLA2水平有关,且两者并非完全独立,可能协同作用于认知功能减退的过程。Objective To investigate the correlation between the efficacy of computer⁃assisted cognitive training(CCT)for mild cognitive impairment and Lp⁃PLA2 and ApoEε4 genes,and discuss the mechanism of their related action.Methods Among the patients confirmed as mild cognitive impairment,55 cases were randomly assigned to the experimental group and 35 cases to the control group.The interventions were CCT for 3 months,3 times per week,20 minutes each time.The neuropsychological scale was used to evaluate the serum Lp⁃PLA2 level and apoEε4 before and after the treatment,and to evaluate the correlation between them.Results The level of cognitive assessment in the experimental group was significantly higher than that in the control group(P<0.05).The level of cognitive changes in the experimental group was similar to that of Lp⁃PLA2(P<0.05)showed significant negative correlation.The cognitive change level of ApoEε4 carriers was significantly higher than that of noncarriers(P<0.05).Whether ApoEε4 is carried or not,the level of Lp⁃PLA2 has statistical difference(P<0.05).Conclusion CCT is effective for patients with mild cognitive impairment,and the results are influenced by APOEε4 gene and the level of Lp⁃PLA2,which are not completely independent,and may synergistically act on the process of cognitive decline.

关 键 词：轻度认知功能障碍 计算机辅助认知训练 APOE基因多态性 脂蛋白相关磷脂酶A2 

分 类 号：R512.91[医药卫生—内科学]