狼疮足细胞病的研究现状及进展  

Research status and recent advances of lupus podocytopathy

作　　者：杨盟 魏巍[1] 刘睿婵[1] 王明奡[1] 隋满姝[1] Yang Meng;Wei Wei;Liu Rui-chan;Wang Ming-ao;Sui Man-shu(Department of Nephrology,First Affiliated Hospital,Harbin Medical University,Harbin 150000,China)

机构地区：[1]哈尔滨医科大学附属第一医院肾内科,150000

出　　处：《临床肾脏病杂志》2021年第7期598-602,共5页Journal Of Clinical Nephrology

摘　　要：狼疮足细胞病(lupus podocytopathy,LP)以广泛足突消失为特征,无外周毛细血管壁增生和免疫复合物沉积,是狼疮肾炎(lupus nephritis,LN)的一种特殊类型。目前LP发病机制并未阐明,糖皮质激素联合非特异性免疫抑制剂的应用可缓解病情,但用药后复发率高是LP治疗的棘手问题。本综述就LP的组织病理、发病机制及治疗的现状进行报道。As a special type of lupus nephritis,lupus podocytopathy(LP)is characterized by diffuse epithelial cell foot process effacement and absence of peripheral capillary wall proliferation and immune complex deposition.Currently the pathogenesis of LP has remained elusive.Using glucocorticoids and immunosuppressive agents can alleviate the severity of disease.However,high recurrence rate of LP has become a thorny problem.This review summarized the histopathology,pathogenesis and treatment of LP.

关 键 词：狼疮肾炎 足细胞病 组织病理学 自噬 利妥昔单抗 

分 类 号：R593.242[医药卫生—内科学]