阿奇霉素和强力霉素治疗泌尿生殖道沙眼衣原体感染的回顾性研究  

Azithromycin versus doxycycline for the treatment of urogenital Chlamydia trachomatis infection——a retrospective study

作　　者：杨立刚 张晓辉 柯吴坚 王柳苑 陈征宇 廖玉英 梁春梅 陈慧茹 龙海莹 YANG Ligang;ZHANG Xiaohui;KE Wujian;WANG Liuyuan;CHEN Zhengyu;LIAO Yuying;LIANG Chunmei;CHEN Huiru;LONG Haiying(Dermatology Hospital,Southern Medical University,Guangzhou 510091,China)

机构地区：[1]南方医科大学皮肤病医院,广东广州510091

出　　处：《皮肤性病诊疗学杂志》2021年第3期159-163,共5页Journal of Diagnosis and Therapy on Dermato-venereology

基　　金：Supported by the Bureau of Science and Information Technology of Guangzhou Municipality(No.201704020219)。

摘　　要：目的:评价阿奇霉素1 g疗法和强力霉素7 d疗法在临床治疗泌尿生殖道沙眼衣原体感染的疗效。方法:对2017年5月至2019年5月门诊所有衣原体检测阳性的患者病例进行回顾性研究,剔除未按标准剂量及疗程、未接受判愈试验、接受其他可能影响疗效药物治疗患者资料。结果:68例初始接受单剂量阿奇霉素1 g治疗的患者,微生物治愈率为79.4%(54/68),19例接受强力霉素7 d疗法治疗的患者微生物治愈率为100%(19/19)。使用不同厂家药物,在治疗完成后较短的时间进行判愈试验可能会导致微生物治愈率被低估。结论:结果支持7 d强力霉素作为泌尿生殖道衣原体感染一线治疗方案。1 g单剂量阿奇霉素用药方便,并可用于孕妇,作为替代治疗方法。Objective:The objective of this retrospective study was to compare the efficacy of azithromycin versus doxycycline in the treatment of urogenital Chlamydia trachomatis infection.Methods:A retrospective study was conducted on all patients who tested positive for Chlamydia in our clinic from May 2017 to May 2019.Patients who did not follow the standard dose and course of treatment,did not receive the test-of-cure,or received other drugs that may affect the efficacy were excluded.Results:Of the 68 patients who initially received a 1 g single dose azithromycin,the total microbiological cure rate was 79.4%(54/68),while the microbiological cure rate in 19 patients who received doxycycline treatment was 100%(19/19).Use of drugs from different manufacturers and shorter time after completion of treatment to perform test-of-cure might lead to the possibility of underestimation of microbiological cure rate.Conclusions:These results suggest that 7-day doxycycline should be recommended as the 1 st line treatment for urogenital Chlamydia infection.Considering the convenient dosage,ong-gram single dose of azithromycin could be recommended as an alternative treatment for urogenital Chlamydia infection.

关 键 词：衣原体 阿奇霉素 多西环素 

分 类 号：R691.3[医药卫生—泌尿科学]